C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: protein kinase, cGMP-dependent, type I
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000185532 PRKG1 9606 + 10:50991358-52298350 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000373975 PRKG1-005 52046777-52294176 protein_coding
  ENST00000373976 PRKG1-004 51153279-52062862 protein_coding
  ENST00000373980 PRKG1-002 51074174-52298350 protein_coding
  ENST00000373985 PRKG1-001 50991358-52298350 protein_coding
  ENST00000401604 PRKG1-201 51804580-52298348 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000373975ENST00000373980ENST00000373985ENST00000401604
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000373975 N/A N/A 0.629±0.00 N/A N/A N/A N/A 0.098±0.00 N/A N/A 2.238±0.00 N/A N/A 1.163±0.00
ENST00000373980 0.432±0.00 1.577±0.00 0.244±0.00 1.450±0.41 0.442±0.00 1.168±0.23 1.291±0.46 0.349±0.00 5.285±0.00 0.830±0.00 1.583±0.00 0.477±0.13 0.605±0.40 1.517±0.75
ENST00000373985 1.417±0.00 1.239±0.00 0.373±0.00 N/A 1.140±0.00 1.511±0.31 3.291±0.00 0.725±0.61 0.550±0.50 3.259±0.61 1.289±0.00 0.503±0.03 1.241±0.24 1.024±0.00
ENST00000401604 N/A N/A N/A N/A 1.151±0.64 2.492±0.00 1.234±0.00 N/A 0.080±0.00 0.862±0.00 N/A 0.984±0.31 0.297±0.04 2.138±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0006EK CIL_0006EK_0002 CGP 10:50799409-52298350
CIL_0000ID CIL_0000ID_0001 CGP 10:50991358-52298350

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001764 IEA neuron migration
GO:0004672 IEA protein kinase activity
GO:0004674 IEA protein serine/threonine kinase activity
GO:0004692 IDA cGMP-dependent protein kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005246 IDA calcium channel regulator activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005737 IDA cytoplasm
GO:0005794 IEA Golgi apparatus
GO:0005829 TAS cytosol
GO:0005886 IDA plasma membrane
GO:0006468 IEA protein phosphorylation
GO:0007165 TAS signal transduction
GO:0007596 TAS blood coagulation
GO:0016358 IEA dendrite development
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0019934 IEA cGMP-mediated signaling
GO:0030036 TAS actin cytoskeleton organization
GO:0030553 IEA cGMP binding
GO:0030900 IEA forebrain development
GO:0043087 IMP regulation of GTPase activity
GO:0045986 IEA negative regulation of smooth muscle contraction
GO:0060087 IEA relaxation of vascular smooth muscle
GO:0090331 IMP negative regulation of platelet aggregation

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000020656 prkg1a protein kinase, cGMP-dependent, type Ia protein_coding Danio_rerio
ENSDARG00000031702 prkg1b protein kinase, cGMP-dependent, type Ib protein_coding Danio_rerio
ENSMUSG00000052920 Prkg1 protein kinase, cGMP-dependent, type I protein_coding Mus_musculus

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