C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: WW domain containing oxidoreductase
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000186153 WWOX 9606 + 16:78099413-79212667 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000355860 WWOX-001 78099679-78278696 protein_coding
  ENST00000402655 WWOX-003 78099654-79212667 protein_coding
  ENST00000406884 WWOX-004 78099654-79212667 protein_coding
  ENST00000408984 WWOX-006 78099694-78780449 protein_coding
  ENST00000539474 WWOX-016 78099654-79212667 protein_coding
  ENST00000561846 WWOX-015 78099735-78281049 processed_transcript
  ENST00000562214 WWOX-008 78099656-78119076 processed_transcript
  ENST00000562639 WWOX-013 78130049-78432603 processed_transcript
  ENST00000563358 WWOX-011 78099786-78278703 processed_transcript
  ENST00000565562 WWOX-010 78099734-78111992 processed_transcript
  ENST00000565791 WWOX-012 78145917-78270586 processed_transcript
  ENST00000566103 WWOX-014 79196359-79212300 processed_transcript
  ENST00000566662 WWOX-009 78099656-78424956 nonsense_mediated_decay
  ENST00000566780 WWOX-005 78099413-79212667 protein_coding
  ENST00000569332 WWOX-002 78099626-79212319 nonsense_mediated_decay
  ENST00000569818 WWOX-007 78099675-78100199 protein_coding
  ENST00000620008 WWOX-201 78424871-78432752 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000355860ENST00000402655ENST00000406884ENST00000408984ENST00000539474ENST00000561846ENST00000562214ENST00000565562ENST00000565791ENST00000566103ENST00000566780ENST00000569332ENST00000569818ENST00000620008
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000355860 N/A N/A N/A 1.081±0.00 N/A N/A N/A 2.863±0.00 1.738±0.00 1.210±0.00 N/A 1.407±0.00 N/A N/A
ENST00000402655 N/A N/A N/A N/A 0.926±0.00 N/A 0.198±0.00 0.337±0.00 0.681±0.00 N/A 1.828±0.00 1.498±0.57 1.622±0.36 1.921±0.00
ENST00000406884 0.821±0.00 N/A N/A 6.044±0.00 3.890±0.00 1.270±0.00 0.778±0.00 0.711±0.35 2.148±0.00 1.181±0.66 N/A 2.586±0.58 1.535±0.68 1.312±0.00
ENST00000408984 N/A N/A 1.586±0.00 N/A N/A N/A N/A N/A 1.016±0.00 N/A N/A N/A 1.000±0.00 N/A
ENST00000539474 N/A 2.265±0.00 N/A N/A N/A N/A N/A 1.373±0.00 N/A N/A N/A N/A N/A N/A
ENST00000561846 N/A N/A N/A N/A N/A N/A N/A N/A N/A 1.320±0.00 N/A N/A N/A N/A
ENST00000562214 N/A N/A N/A 2.346±0.00 3.031±0.00 1.141±0.00 0.878±0.00 N/A 1.173±0.00 N/A 0.820±0.00 1.391±0.00 N/A 5.732±0.00
ENST00000565562 3.468±0.00 3.653±0.00 N/A N/A 1.271±0.00 1.959±1.06 1.669±0.00 N/A N/A N/A 0.494±0.00 N/A N/A 6.279±0.00
ENST00000565791 N/A N/A N/A N/A N/A 0.419±0.00 N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000566103 N/A N/A N/A N/A N/A N/A N/A N/A 1.724±0.00 N/A N/A N/A N/A N/A
ENST00000566780 0.780±0.00 N/A N/A 3.952±0.00 N/A 0.588±0.00 0.536±0.00 2.133±0.00 N/A 1.020±0.00 N/A 2.656±1.46 0.878±0.10 3.231±0.39
ENST00000569332 1.628±0.00 2.013±0.00 N/A 3.036±0.00 2.133±0.00 0.686±0.00 N/A 1.133±0.00 N/A 3.642±0.00 N/A N/A N/A 1.793±0.00
ENST00000569818 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 8.819±0.00 6.825±0.00 21.219±0.00
ENST00000620008 N/A N/A N/A N/A N/A N/A N/A N/A 3.609±0.00 N/A 2.101±0.00 2.523±0.00 3.840±1.08 N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008I7 CIL_0008I7_0001 VISTA 16:77875854-78477465
CIL_0003OH CIL_0003OH_0001 CGP 16:78022515-79212667
CIL_0007SZ CIL_0007SZ_0001 VISTA 16:78053124-78654788
CIL_00085A CIL_00085A_0001 VISTA 16:78063958-78665023
CIL_0001PE CIL_0001PE_0001 CGP 16:78099413-79600714

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001649 IEA osteoblast differentiation
GO:0005515 IPI:IEA protein binding
GO:0005634 IDA nucleus
GO:0005737 TAS cytoplasm
GO:0005739 ISS mitochondrion
GO:0005794 IDA Golgi apparatus
GO:0005829 IDA cytosol
GO:0005886 IDA plasma membrane
GO:0005902 IDA microvillus
GO:0008152 IEA metabolic process
GO:0008202 TAS steroid metabolic process
GO:0016055 IEA Wnt signaling pathway
GO:0016491 TAS:IEA oxidoreductase activity
GO:0019899 IPI enzyme binding
GO:0030178 IDA negative regulation of Wnt signaling pathway
GO:0045944 ISS positive regulation of transcription from RNA polymerase II promoter
GO:0046983 TAS protein dimerization activity
GO:0048037 TAS cofactor binding
GO:0048705 ISS skeletal system morphogenesis
GO:0050662 TAS coenzyme binding
GO:0055114 TAS oxidation-reduction process
GO:0071560 IDA cellular response to transforming growth factor beta stimulus
GO:0072332 IEA intrinsic apoptotic signaling pathway by p53 class mediator
GO:0097191 IEA extrinsic apoptotic signaling pathway
GO:2001238 ISS positive regulation of extrinsic apoptotic signaling pathway
GO:2001241 IEA positive regulation of extrinsic apoptotic signaling pathway in absence of ligand

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000007614 wwox WW domain containing oxidoreductase protein_coding Danio_rerio
ENSMUSG00000004637 Wwox WW domain-containing oxidoreductase protein_coding Mus_musculus

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