C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: WW domain-containing oxidoreductase
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000004637 Wwox 10090 + 8:114439655-115352708 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000004756 Wwox-001 114439655-115352708 protein_coding
  ENSMUST00000109107 Wwox-002 114439702-114474529 protein_coding
  ENSMUST00000109108 Wwox-004 114439695-114875238 protein_coding
  ENSMUST00000159870 Wwox-007 114712167-115019702 processed_transcript
  ENSMUST00000160005 Wwox-005 114439702-114453818 processed_transcript
  ENSMUST00000160205 Wwox-008 114608436-114706324 processed_transcript
  ENSMUST00000160862 Wwox-003 114439695-114718679 protein_coding
  ENSMUST00000161753 Wwox-009 114448210-114514288 processed_transcript
  ENSMUST00000162052 Wwox-006 114712167-115352143 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000004756ENSMUST00000109108ENSMUST00000160005ENSMUST00000160862ENSMUST00000162052
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000004756 4.897±1.21 6.061±5.19 3.146±0.05 2.591±0.50 3.734±1.38 3.387±1.43 1.025±0.25 7.261±1.56 1.391±0.33 4.627±1.38 1.196±0.09 6.961±2.38 1.301±0.64 6.228±0.24
ENSMUST00000109108 N/A N/A N/A N/A 1.412±0.00 1.323±0.22 N/A 1.391±0.00 0.722±0.27 N/A N/A 2.471±0.39 0.623±0.07 N/A
ENSMUST00000160005 0.781±0.13 N/A 0.644±0.03 0.673±0.00 0.945±0.32 1.321±0.00 0.461±0.04 N/A 0.511±0.12 1.122±0.21 0.754±0.09 2.087±0.65 0.498±0.22 2.669±0.13
ENSMUST00000160862 1.204±0.03 N/A N/A N/A 1.731±0.75 N/A 0.734±0.30 1.866±0.00 0.940±0.35 1.173±0.00 N/A 2.594±0.23 N/A N/A
ENSMUST00000162052 N/A 14.488±2.42 N/A 10.252±0.00 3.351±0.06 3.667±0.93 N/A 4.225±0.00 N/A N/A N/A 9.221±2.80 4.110±1.21 52.883±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008I7 CIL_0008I7_0002 VISTA 8:114199211-114800511
CIL_0007SZ CIL_0007SZ_0002 VISTA 8:114350145-114951788
CIL_00085A CIL_00085A_0002 VISTA 8:114357896-114958964
CIL_0008ID CIL_0008ID_0002 VISTA 8:114391554-114992470
CIL_0003OH CIL_0003OH_0002 CGP 8:114418086-115352708
CIL_0001PE CIL_0001PE_0002 CGP 8:114439655-115707794

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001105 NAS RNA polymerase II transcription coactivator activity
GO:0001649 IMP osteoblast differentiation
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005737 ISS cytoplasm
GO:0005739 IDA mitochondrion
GO:0005794 IEA Golgi apparatus
GO:0005829 IEA cytosol
GO:0005886 IEA plasma membrane
GO:0005902 IEA microvillus
GO:0016055 IEA Wnt signaling pathway
GO:0016491 IEA oxidoreductase activity
GO:0019899 IPI enzyme binding
GO:0030178 ISS negative regulation of Wnt signaling pathway
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0048705 IMP skeletal system morphogenesis
GO:0055114 IEA oxidation-reduction process
GO:0071560 IDA cellular response to transforming growth factor beta stimulus
GO:0072332 IGI intrinsic apoptotic signaling pathway by p53 class mediator
GO:0097191 IDA extrinsic apoptotic signaling pathway
GO:2001238 IMP positive regulation of extrinsic apoptotic signaling pathway
GO:2001241 IDA positive regulation of extrinsic apoptotic signaling pathway in absence of ligand

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000007614 wwox WW domain containing oxidoreductase protein_coding Danio_rerio
ENSG00000186153 WWOX WW domain containing oxidoreductase protein_coding Homo_sapiens

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