C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: beta-site APP-cleaving enzyme 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000186318 BACE1 9606 - 11:117285207-117316259 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000313005 BACE1-001 117285207-117316256 protein_coding
  ENST00000392937 BACE1-006 117285706-117295636 protein_coding
  ENST00000428381 BACE1-002 117289535-117315798 protein_coding
  ENST00000445823 BACE1-004 117289535-117315798 protein_coding
  ENST00000504995 BACE1-008 117293071-117299696 protein_coding
  ENST00000509916 BACE1-010 117290503-117291997 retained_intron
  ENST00000510630 BACE1-007 117289487-117295573 protein_coding
  ENST00000510915 BACE1-009 117291799-117295485 protein_coding
  ENST00000513780 BACE1-003 117289535-117315798 protein_coding
  ENST00000514464 BACE1-005 117293871-117315795 processed_transcript
  ENST00000528053 BACE1-013 117287351-117316259 protein_coding
  ENST00000530824 BACE1-016 117290634-117294441 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungOvaryPlacentaTestisENST00000313005ENST00000392937ENST00000528053
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Ovary Placenta Testis
ENST00000313005 4.315±0.00 1.719±0.00 0.721±0.00 5.320±3.47 3.455±0.00 5.305±0.00 1.835±0.00 1.715±1.12 1.313±0.25 1.228±0.00 4.357±3.18 2.244±0.89 2.541±0.00
ENST00000392937 6.525±0.00 N/A N/A 35.502±0.00 4.001±0.00 N/A N/A 2.766±0.20 4.224±0.00 3.710±0.00 5.378±3.17 2.517±0.60 N/A
ENST00000528053 N/A N/A N/A N/A 1.987±0.00 0.887±0.00 0.693±0.00 1.951±0.00 1.284±0.00 2.709±0.00 1.636±0.00 3.168±0.00 N/A

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001540 IPI beta-amyloid binding
GO:0004175 IEA endopeptidase activity
GO:0004190 IEA:IDA aspartic-type endopeptidase activity
GO:0005515 IPI protein binding
GO:0005768 IDA endosome
GO:0005770 IDA late endosome
GO:0005771 IDA multivesicular body
GO:0005783 IEA endoplasmic reticulum
GO:0005794 IDA Golgi apparatus
GO:0005802 IDA trans-Golgi network
GO:0005886 IDA plasma membrane
GO:0005887 IDA integral component of plasma membrane
GO:0006508 IEA:IDA proteolysis
GO:0006509 TAS membrane protein ectodomain proteolysis
GO:0008233 IEA peptidase activity
GO:0008798 TAS beta-aspartyl-peptidase activity
GO:0016020 IEA membrane
GO:0016021 NAS integral component of membrane
GO:0019899 IPI enzyme binding
GO:0030424 IEA axon
GO:0031410 IEA cytoplasmic vesicle
GO:0050435 IDA beta-amyloid metabolic process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000007177 CABZ01088933.1 Uncharacterized protein protein_coding Danio_rerio
ENSMUSG00000032086 Bace1 beta-site APP cleaving enzyme 1 protein_coding Mus_musculus

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