C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: beta-site APP cleaving enzyme 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000032086 Bace1 10090 + 9:45838580-45864399 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000034591 Bace1-001 45838580-45864399 protein_coding
  ENSMUST00000078111 Bace1-002 45838580-45862484 protein_coding
  ENSMUST00000159499 Bace1-004 45839240-45857173 nonsense_mediated_decay
  ENSMUST00000159970 Bace1-003 45852723-45862219 retained_intron
  ENSMUST00000162559 Bace1-005 45839918-45854707 processed_transcript
  ENSMUST00000162587 Bace1-006 45854627-45860362 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdrenalBrainBreastHeartKidneyLiverMusclePlacentaENSMUST00000034591ENSMUST00000078111ENSMUST00000159970
Transcript ID Adrenal Brain Breast Heart Kidney Liver Muscle Placenta
ENSMUST00000034591 6.386±0.00 12.316±0.41 N/A N/A N/A 5.292±1.43 3.338±0.37 5.129±0.00
ENSMUST00000078111 16.275±1.59 9.646±0.00 12.835±0.00 7.238±1.18 8.079±0.43 N/A 5.477±1.97 9.209±4.77
ENSMUST00000159970 N/A 13.876±1.55 N/A N/A N/A 8.091±1.32 6.847±1.02 9.680±1.54

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007RC CIL_0007RC_0002 VISTA 9:45818249-46421546

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001540 IEA beta-amyloid binding
GO:0004175 IDA endopeptidase activity
GO:0004190 ISS aspartic-type endopeptidase activity
GO:0005515 IPI protein binding
GO:0005768 ISS endosome
GO:0005770 IEA late endosome
GO:0005771 IEA multivesicular body
GO:0005783 IEA endoplasmic reticulum
GO:0005794 ISS Golgi apparatus
GO:0005802 IEA trans-Golgi network
GO:0005886 IEA plasma membrane
GO:0005887 IEA integral component of plasma membrane
GO:0006508 ISS proteolysis
GO:0008233 IEA peptidase activity
GO:0016020 IDA membrane
GO:0019899 IEA enzyme binding
GO:0030424 IDA axon
GO:0031410 IDA cytoplasmic vesicle
GO:0050435 ISS beta-amyloid metabolic process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000007177 CABZ01088933.1 Uncharacterized protein protein_coding Danio_rerio
ENSG00000186318 BACE1 beta-site APP-cleaving enzyme 1 protein_coding Homo_sapiens

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