C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: beta-site APP-cleaving enzyme 1
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000445823 BACE1-004 ENSG00000186318 9606 - 11:117289535-117315798 protein_coding

Expression Patterns

No expression data.

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology

GO IDEvidence TypeGO Description
GO:0001540 IPI beta-amyloid binding
GO:0004190 IEA:IDA aspartic-type endopeptidase activity
GO:0005515 IPI protein binding
GO:0005768 IDA endosome
GO:0005770 IDA late endosome
GO:0005771 IDA multivesicular body
GO:0005783 IEA endoplasmic reticulum
GO:0005794 IDA Golgi apparatus
GO:0005802 IDA trans-Golgi network
GO:0005886 IDA plasma membrane
GO:0005887 IDA integral component of plasma membrane
GO:0006508 IEA:IDA proteolysis
GO:0006509 TAS membrane protein ectodomain proteolysis
GO:0008798 TAS beta-aspartyl-peptidase activity
GO:0016021 NAS integral component of membrane
GO:0019899 IPI enzyme binding
GO:0050435 IDA beta-amyloid metabolic process

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000159970 Bace1-003 retained_intron Mus_musculus 0 1291
ENSMUST00000034591 Bace1-001 protein_coding Mus_musculus 0 1291
ENSMUST00000162587 Bace1-006 protein_coding Mus_musculus 0 1203
ENSMUST00000078111 Bace1-002 protein_coding Mus_musculus 0 802
ENSMUST00000162559 Bace1-005 processed_transcript Mus_musculus 0 255
ENSMUST00000159499 Bace1-004 nonsense_mediated_decay Mus_musculus 0 235

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