C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: beta-site APP-cleaving enzyme 1
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000392937 BACE1-006 ENSG00000186318 9606 - 11:117285706-117295636 protein_coding

Homo sapiens EnsemblGRCh38

Genome
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Genes
Structures from Ensembl
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Transcripts
Structures from Ensembl
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Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeBrainBreastKidneyLiverLungOvaryPlacentaENST00000392937
Transcript ID Adipose Brain Breast Kidney Liver Lung Ovary Placenta
ENST00000392937 6.525±0.00 35.502±0.00 4.001±0.00 2.766±0.20 4.224±0.00 3.710±0.00 5.378±3.17 2.517±0.60

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology

GO IDEvidence TypeGO Description
GO:0001540 IPI beta-amyloid binding
GO:0004190 IEA:IDA aspartic-type endopeptidase activity
GO:0005515 IPI protein binding
GO:0005768 IDA endosome
GO:0005770 IDA late endosome
GO:0005771 IDA multivesicular body
GO:0005783 IEA endoplasmic reticulum
GO:0005794 IDA Golgi apparatus
GO:0005802 IDA trans-Golgi network
GO:0005886 IDA plasma membrane
GO:0005887 IDA integral component of plasma membrane
GO:0006508 IEA:IDA proteolysis
GO:0006509 TAS membrane protein ectodomain proteolysis
GO:0008798 TAS beta-aspartyl-peptidase activity
GO:0016021 NAS integral component of membrane
GO:0019899 IPI enzyme binding
GO:0050435 IDA beta-amyloid metabolic process

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000034591 Bace1-001 protein_coding Mus_musculus 0 1997
ENSMUST00000159970 Bace1-003 retained_intron Mus_musculus 0 1668
ENSMUST00000162587 Bace1-006 protein_coding Mus_musculus 0 1242
ENSMUST00000078111 Bace1-002 protein_coding Mus_musculus 0 1175
ENSMUST00000058720 Rnf214-001 protein_coding Mus_musculus 0 305
ENSMUST00000161187 Rnf214-005 protein_coding Mus_musculus 0 305
ENSMUST00000161203 Rnf214-003 protein_coding Mus_musculus 0 305
ENSMUST00000162559 Bace1-005 processed_transcript Mus_musculus 3e-25 122

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