C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: dihydropyrimidine dehydrogenase
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000188641 DPYD 9606 - 1:97077743-97921049 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000306031 DPYD-002 97719758-97921049 protein_coding
  ENST00000370192 DPYD-001 97077743-97921023 protein_coding
  ENST00000460019 DPYD-003 97855030-97920997 processed_transcript
  ENST00000474241 DPYD-004 97691207-97721654 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000306031ENST00000370192ENST00000460019
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000306031 N/A N/A N/A 0.674±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000370192 8.609±0.00 4.201±0.00 2.688±0.00 0.773±0.25 4.608±0.54 7.048±2.83 2.249±0.70 6.212±0.86 7.441±0.36 7.212±2.03 1.857±0.39 4.245±3.07 1.475±0.45 5.009±0.00
ENST00000460019 N/A N/A 5.911±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007J2 CIL_0007J2_0001 UCNEbase 1:95311769-97837577
CIL_0007C5 CIL_0007C5_0002 CGP 1:96721665-97921049
CIL_0008IK CIL_0008IK_0001 VISTA 1:96844935-97446185

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004152 IEA dihydroorotate dehydrogenase activity
GO:0005737 IDA cytoplasm
GO:0005829 IDA cytosol
GO:0006145 IMP purine nucleobase catabolic process
GO:0006206 TAS pyrimidine nucleobase metabolic process
GO:0006208 ISS pyrimidine nucleobase catabolic process
GO:0006210 IDA thymine catabolic process
GO:0006212 IDA uracil catabolic process
GO:0006214 IDA thymidine catabolic process
GO:0006222 IEA UMP biosynthetic process
GO:0008033 IEA tRNA processing
GO:0016491 IEA oxidoreductase activity
GO:0016627 IEA oxidoreductase activity, acting on the CH-CH group of donors
GO:0017113 ISS dihydropyrimidine dehydrogenase (NADP+) activity
GO:0017150 IEA tRNA dihydrouridine synthase activity
GO:0019483 IEA beta-alanine biosynthetic process
GO:0042803 ISS protein homodimerization activity
GO:0044281 TAS small molecule metabolic process
GO:0046135 TAS pyrimidine nucleoside catabolic process
GO:0046872 IEA metal ion binding
GO:0050660 ISS flavin adenine dinucleotide binding
GO:0050661 ISS NADP binding
GO:0051536 IEA iron-sulfur cluster binding
GO:0051539 IEA 4 iron, 4 sulfur cluster binding
GO:0055086 TAS nucleobase-containing small molecule metabolic process
GO:0055114 IEA oxidation-reduction process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000010267 dpydb dihydropyrimidine dehydrogenase b protein_coding Danio_rerio
ENSDARG00000071482 dpyda dihydropyrimidine dehydrogenase a protein_coding Danio_rerio
ENSDARG00000086464 DPYD (3 of 5) dihydropyrimidine dehydrogenase protein_coding Danio_rerio
ENSDARG00000086853 DPYD (4 of 5) dihydropyrimidine dehydrogenase protein_coding Danio_rerio
ENSDARG00000089675 CR855273.1 Uncharacterized protein protein_coding Danio_rerio
ENSMUSG00000033308 Dpyd dihydropyrimidine dehydrogenase protein_coding Mus_musculus

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