C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: filamin A, alpha
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000196924 FLNA 9606 - X:154348524-154374638 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000344736 FLNA-010 154348784-154371288 protein_coding
  ENST00000360319 FLNA-001 154348526-154371283 protein_coding
  ENST00000369850 FLNA-002 154348648-154374626 protein_coding
  ENST00000369856 FLNA-022 154348529-154371222 protein_coding
  ENST00000415241 FLNA-019 154352553-154353598 nonsense_mediated_decay
  ENST00000420627 FLNA-021 154348524-154371203 nonsense_mediated_decay
  ENST00000422373 FLNA-201 154348532-154374638 protein_coding
  ENST00000438732 FLNA-015 154353296-154354889 protein_coding
  ENST00000444578 FLNA-016 154351581-154353169 protein_coding
  ENST00000462590 FLNA-009 154348922-154350355 retained_intron
  ENST00000465144 FLNA-013 154364632-154365207 retained_intron
  ENST00000466319 FLNA-005 154357541-154358664 processed_transcript
  ENST00000466325 FLNA-020 154352538-154353456 retained_intron
  ENST00000474072 FLNA-006 154354030-154354680 retained_intron
  ENST00000474358 FLNA-007 154351728-154352783 retained_intron
  ENST00000490936 FLNA-003 154348648-154359638 retained_intron
  ENST00000498411 FLNA-017 154348530-154352883 processed_transcript
  ENST00000498491 FLNA-008 154348920-154351203 processed_transcript
  ENST00000610817 FLNA-202 154348532-154374638 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000344736ENST00000360319ENST00000369850ENST00000369856ENST00000422373ENST00000490936ENST00000498491ENST00000610817
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000344736 N/A N/A N/A N/A 20.794±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000360319 190.217±0.00 220.351±0.00 5.269±0.00 4.106±3.46 64.331±0.00 187.893±0.00 21.653±0.00 N/A N/A 9.620±0.00 24.114±0.00 90.366±87.53 50.483±20.28 87.619±76.47
ENST00000369850 128.466±0.00 192.196±0.00 N/A 17.037±0.00 57.551±0.00 404.876±0.00 15.085±0.00 68.039±0.00 N/A 98.744±0.00 26.686±0.00 134.689±0.00 N/A 103.289±0.00
ENST00000369856 N/A N/A N/A 3.692±2.43 79.678±0.00 N/A N/A 2.161±0.00 7.196±0.00 55.695±36.36 N/A 71.070±45.02 70.139±9.33 N/A
ENST00000422373 N/A N/A 4.971±0.00 0.612±0.00 76.328±0.00 103.169±0.00 9.483±0.00 1.204±0.00 341.603±0.00 14.847±0.00 7.214±0.00 11.946±0.00 19.430±0.00 N/A
ENST00000490936 N/A N/A N/A N/A N/A N/A N/A N/A N/A 75.579±0.00 N/A 83.790±0.00 N/A 11.030±0.00
ENST00000498491 N/A N/A N/A N/A N/A 1097.570±0.00 N/A 202.534±0.00 19.690±0.00 N/A N/A N/A N/A N/A
ENST00000610817 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 40.583±0.00 N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0001L8 CIL_0001L8_0001 CGP X:154295671-154374638
CIL_0001L9 CIL_0001L9_0001 CGP X:154348524-154381523

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001837 IEA epithelial to mesenchymal transition
GO:0001948 IDA glycoprotein binding
GO:0002576 TAS platelet degranulation
GO:0004871 IMP signal transducer activity
GO:0005080 IEA protein kinase C binding
GO:0005515 IEA protein binding
GO:0005576 TAS extracellular region
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0005802 IEA trans-Golgi network
GO:0005829 TAS cytosol
GO:0005884 IEA actin filament
GO:0005886 IDA plasma membrane
GO:0005925 IDA focal adhesion
GO:0007195 IMP adenylate cyclase-inhibiting dopamine receptor signaling pathway
GO:0007596 TAS blood coagulation
GO:0008134 IPI transcription factor binding
GO:0015629 IDA actin cytoskeleton
GO:0016020 IDA membrane
GO:0017048 IDA Rho GTPase binding
GO:0017160 IDA Ral GTPase binding
GO:0030036 IEA actin cytoskeleton organization
GO:0030168 TAS platelet activation
GO:0030863 IEA cortical cytoskeleton
GO:0031267 IDA small GTPase binding
GO:0031523 IDA Myb complex
GO:0031532 IDA actin cytoskeleton reorganization
GO:0031852 IEA mu-type opioid receptor binding
GO:0034329 TAS cell junction assembly
GO:0034394 IDA protein localization to cell surface
GO:0034988 IDA Fc-gamma receptor I complex binding
GO:0042177 IMP negative regulation of protein catabolic process
GO:0042384 IMP cilium assembly
GO:0042789 IEA mRNA transcription from RNA polymerase II promoter
GO:0042803 IDA protein homodimerization activity
GO:0042993 IMP positive regulation of transcription factor import into nucleus
GO:0043025 IEA neuronal cell body
GO:0043113 IDA receptor clustering
GO:0043123 IMP positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043198 IEA dendritic shaft
GO:0043234 IEA protein complex
GO:0043433 IDA negative regulation of sequence-specific DNA binding transcription factor activity
GO:0044822 IDA poly(A) RNA binding
GO:0045022 IEA early endosome to late endosome transport
GO:0045184 IDA establishment of protein localization
GO:0046332 IEA SMAD binding
GO:0048365 IDA Rac GTPase binding
GO:0048471 IEA perinuclear region of cytoplasm
GO:0050821 IMP protein stabilization
GO:0051015 IEA actin filament binding
GO:0051220 IMP cytoplasmic sequestering of protein
GO:0051764 IDA actin crosslink formation
GO:0070062 IDA extracellular vesicular exosome
GO:0070527 IMP platelet aggregation
GO:0090307 IDA spindle assembly involved in mitosis
GO:0097440 IEA apical dendrite

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000074201 flna filamin A, alpha (actin binding protein 280) protein_coding Danio_rerio
ENSMUSG00000031328 Flna filamin, alpha protein_coding Mus_musculus

Loading