C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: filamin, alpha
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000031328 Flna 10090 - X:74223461-74249820 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000033699 Flna-003 74223541-74246555 protein_coding
  ENSMUST00000101454 Flna-201 74223463-74246534 protein_coding
  ENSMUST00000114299 Flna-002 74223461-74249820 protein_coding
  ENSMUST00000124950 Flna-006 74226448-74227620 retained_intron
  ENSMUST00000127463 Flna-014 74228380-74230570 protein_coding
  ENSMUST00000127924 Flna-008 74227852-74229063 nonsense_mediated_decay
  ENSMUST00000130007 Flna-013 74223789-74246364 protein_coding
  ENSMUST00000130203 Flna-007 74230696-74235962 processed_transcript
  ENSMUST00000133174 Flna-009 74228086-74228799 retained_intron
  ENSMUST00000133288 Flna-004 74236081-74237925 processed_transcript
  ENSMUST00000133609 Flna-010 74227237-74227968 retained_intron
  ENSMUST00000141528 Flna-011 74224834-74226789 retained_intron
  ENSMUST00000144429 Flna-001 74223461-74246398 nonsense_mediated_decay
  ENSMUST00000150554 Flna-015 74226872-74228489 protein_coding
  ENSMUST00000156766 Flna-016 74224810-74226479 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000033699ENSMUST00000101454ENSMUST00000114299ENSMUST00000130007ENSMUST00000144429
Transcript ID Adipose Adrenal Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000033699 N/A N/A 8.944±0.00 N/A N/A N/A N/A N/A N/A 1.891±0.56 N/A N/A 1.022±0.00
ENSMUST00000101454 48.271±3.61 8.954±0.00 13.949±9.61 22.215±0.00 N/A 5.712±0.00 6.395±1.45 6.830±4.85 N/A 3.070±1.08 68.619±26.45 21.685±10.16 1.085±0.37
ENSMUST00000114299 99.668±74.99 16.822±3.00 N/A 52.342±9.78 172.385±21.23 22.174±3.54 14.674±4.25 3.353±1.83 82.706±19.63 2.327±1.00 182.666±35.96 34.668±24.82 9.278±4.28
ENSMUST00000130007 N/A N/A 3.220±0.00 N/A N/A N/A N/A N/A N/A N/A 72.682±0.00 10.735±3.21 2.003±0.00
ENSMUST00000144429 127.886±77.78 14.077±4.34 38.855±10.91 28.331±11.41 73.672±17.76 7.867±3.59 9.189±2.70 3.795±2.50 37.822±2.23 1.397±0.23 165.661±58.30 20.654±9.38 3.745±1.22

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0001L8 CIL_0001L8_0002 CGP X:74177259-74249820
CIL_0001L9 CIL_0001L9_0002 CGP X:74223461-74261548

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001837 IGI epithelial to mesenchymal transition
GO:0001948 ISS glycoprotein binding
GO:0003779 TAS actin binding
GO:0004871 ISS signal transducer activity
GO:0005080 IDA protein kinase C binding
GO:0005515 IPI protein binding
GO:0005634 ISS nucleus
GO:0005737 ISS cytoplasm
GO:0005802 IDA trans-Golgi network
GO:0005829 IEA cytosol
GO:0005884 IEA actin filament
GO:0005886 ISS plasma membrane
GO:0005925 IEA focal adhesion
GO:0007195 ISS adenylate cyclase-inhibiting dopamine receptor signaling pathway
GO:0008134 ISS transcription factor binding
GO:0015629 IEA actin cytoskeleton
GO:0016020 IEA membrane
GO:0017048 ISS Rho GTPase binding
GO:0017160 IEA Ral GTPase binding
GO:0030036 IGI actin cytoskeleton organization
GO:0030863 IEA cortical cytoskeleton
GO:0031267 IEA small GTPase binding
GO:0031523 ISO Myb complex
GO:0031532 ISS actin cytoskeleton reorganization
GO:0031852 IEA mu-type opioid receptor binding
GO:0034394 ISS protein localization to cell surface
GO:0034988 ISS Fc-gamma receptor I complex binding
GO:0042177 ISS negative regulation of protein catabolic process
GO:0042384 IEA cilium assembly
GO:0042789 IEA mRNA transcription from RNA polymerase II promoter
GO:0042803 IEA protein homodimerization activity
GO:0042993 ISS positive regulation of transcription factor import into nucleus
GO:0043025 IEA neuronal cell body
GO:0043113 ISS receptor clustering
GO:0043123 ISS positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043198 IEA dendritic shaft
GO:0043234 IEA protein complex
GO:0043433 ISS negative regulation of sequence-specific DNA binding transcription factor activity
GO:0044822 IEA poly(A) RNA binding
GO:0045022 IDA early endosome to late endosome transport
GO:0045184 ISS establishment of protein localization
GO:0046332 IEA SMAD binding
GO:0048365 ISS Rac GTPase binding
GO:0048471 IEA perinuclear region of cytoplasm
GO:0050821 ISS protein stabilization
GO:0051015 ISS actin filament binding
GO:0051220 ISS cytoplasmic sequestering of protein
GO:0051764 ISS actin crosslink formation
GO:0070062 IEA extracellular vesicular exosome
GO:0070527 IEA platelet aggregation
GO:0090307 ISO spindle assembly involved in mitosis
GO:0097440 IEA apical dendrite

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000074201 flna filamin A, alpha (actin binding protein 280) protein_coding Danio_rerio
ENSG00000196924 FLNA filamin A, alpha protein_coding Homo_sapiens

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