C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: interleukin-1 receptor-associated kinase 4
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000198001 IRAK4 9606 + 12:43758944-43789543 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000431837 IRAK4-201 43758944-43789543 protein_coding
  ENST00000440781 IRAK4-005 43758944-43786975 protein_coding
  ENST00000448290 IRAK4-001 43758955-43788096 protein_coding
  ENST00000546780 IRAK4-009 43758967-43768592 retained_intron
  ENST00000547101 IRAK4-004 43758961-43786903 nonsense_mediated_decay
  ENST00000547521 IRAK4-007 43758951-43786414 nonsense_mediated_decay
  ENST00000547928 IRAK4-012 43773795-43782472 retained_intron
  ENST00000550361 IRAK4-008 43759036-43772956 nonsense_mediated_decay
  ENST00000550386 IRAK4-003 43758961-43786903 nonsense_mediated_decay
  ENST00000550615 IRAK4-006 43758950-43786750 nonsense_mediated_decay
  ENST00000550616 IRAK4-011 43758950-43771326 protein_coding
  ENST00000551736 IRAK4-002 43758961-43786903 protein_coding
  ENST00000552309 IRAK4-010 43758967-43782490 nonsense_mediated_decay
  ENST00000613694 IRAK4-202 43758944-43789543 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000431837ENST00000440781ENST00000448290ENST00000547101ENST00000547521ENST00000550615ENST00000551736ENST00000613694
Transcript ID Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000431837 2.390±0.00 0.161±0.00 0.729±0.00 N/A 2.259±0.00 0.291±0.00 N/A N/A N/A N/A N/A N/A N/A
ENST00000440781 N/A 0.622±0.00 N/A 1.788±0.00 N/A N/A N/A N/A 3.662±0.00 N/A N/A N/A N/A
ENST00000448290 N/A N/A N/A 1.400±0.00 1.112±0.00 0.329±0.00 1.011±0.00 N/A 1.405±0.00 0.217±0.00 0.860±0.00 0.885±0.19 N/A
ENST00000547101 N/A N/A 0.511±0.00 N/A N/A N/A N/A N/A 0.986±0.00 N/A N/A N/A N/A
ENST00000547521 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 1.107±0.00
ENST00000550615 N/A N/A N/A N/A N/A N/A 0.971±0.00 N/A N/A N/A N/A N/A N/A
ENST00000551736 N/A 0.564±0.00 N/A N/A 0.986±0.00 0.196±0.00 N/A N/A N/A N/A N/A N/A 1.117±0.00
ENST00000613694 N/A 0.151±0.00 N/A N/A N/A N/A N/A 0.504±0.00 0.496±0.00 N/A 0.615±0.08 N/A 1.600±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0006R6 CIL_0006R6_0001 CGP 12:43728607-43789543
CIL_0006R5 CIL_0006R5_0001 CGP 12:43758944-43806375

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000287 IEA magnesium ion binding
GO:0001816 IEA cytokine production
GO:0002224 TAS toll-like receptor signaling pathway
GO:0002755 TAS MyD88-dependent toll-like receptor signaling pathway
GO:0004672 EXP:IEA protein kinase activity
GO:0004674 TAS:IEA protein serine/threonine kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005149 IEA interleukin-1 receptor binding
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005615 IEA extracellular space
GO:0005829 TAS cytosol
GO:0005886 TAS plasma membrane
GO:0006468 IEA protein phosphorylation
GO:0007165 IEA signal transduction
GO:0007254 IEA JNK cascade
GO:0010008 TAS endosome membrane
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0019221 IEA cytokine-mediated signaling pathway
GO:0034134 TAS toll-like receptor 2 signaling pathway
GO:0034142 TAS toll-like receptor 4 signaling pathway
GO:0034146 TAS toll-like receptor 5 signaling pathway
GO:0034162 TAS toll-like receptor 9 signaling pathway
GO:0034166 TAS toll-like receptor 10 signaling pathway
GO:0038123 TAS toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124 TAS toll-like receptor TLR6:TLR2 signaling pathway
GO:0043123 IMP positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045087 TAS innate immune response
GO:0048661 IEA positive regulation of smooth muscle cell proliferation

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000010657 irak4 interleukin-1 receptor-associated kinase 4 protein_coding Danio_rerio
ENSMUSG00000059883 Irak4 interleukin-1 receptor-associated kinase 4 protein_coding Mus_musculus

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