C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: interleukin-1 receptor-associated kinase 4
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000448290 IRAK4-001 ENSG00000198001 9606 + 12:43758955-43788096 protein_coding

Homo sapiens EnsemblGRCh38

Genome
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Genes
Structures from Ensembl
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Transcripts
Structures from Ensembl
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Expression Patterns

Heat Map
Numeric Values
Transcript'; BreastColonHeartKidneyLungMuscleOvaryPlacentaENST00000448290
Transcript ID Breast Colon Heart Kidney Lung Muscle Ovary Placenta
ENST00000448290 1.400±0.00 1.112±0.00 0.329±0.00 1.011±0.00 1.405±0.00 0.217±0.00 0.860±0.00 0.885±0.19

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0006R6 CIL_0006R6_0001 CGP 12:43728607-43789543
CIL_0006R5 CIL_0006R5_0001 CGP 12:43758944-43806375

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000287 IEA magnesium ion binding
GO:0001816 IEA cytokine production
GO:0002224 TAS toll-like receptor signaling pathway
GO:0002755 TAS MyD88-dependent toll-like receptor signaling pathway
GO:0004672 EXP:IEA protein kinase activity
GO:0004674 TAS:IEA protein serine/threonine kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005149 IEA interleukin-1 receptor binding
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005615 IEA extracellular space
GO:0005829 TAS cytosol
GO:0005886 TAS plasma membrane
GO:0006468 IEA protein phosphorylation
GO:0007165 IEA signal transduction
GO:0007254 IEA JNK cascade
GO:0010008 TAS endosome membrane
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0019221 IEA cytokine-mediated signaling pathway
GO:0034134 TAS toll-like receptor 2 signaling pathway
GO:0034142 TAS toll-like receptor 4 signaling pathway
GO:0034146 TAS toll-like receptor 5 signaling pathway
GO:0034162 TAS toll-like receptor 9 signaling pathway
GO:0034166 TAS toll-like receptor 10 signaling pathway
GO:0038123 TAS toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124 TAS toll-like receptor TLR6:TLR2 signaling pathway
GO:0043123 IMP positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045087 TAS innate immune response
GO:0048661 IEA positive regulation of smooth muscle cell proliferation

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000074936 Irak4-001 protein_coding Mus_musculus 0 1003
ENSMUST00000109248 Irak4-002 protein_coding Mus_musculus 0 968
ENSMUST00000183332 Rbm4b-007 retained_intron Mus_musculus 0.00005 55

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