C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: interleukin-1 receptor-associated kinase 4
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000059883 Irak4 10090 + 15:94543643-94581815 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000074936 Irak4-001 94543643-94568306 protein_coding
  ENSMUST00000109248 Irak4-002 94543672-94581815 protein_coding
  ENSMUST00000138306 Irak4-003 94543653-94556953 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000074936ENSMUST00000138306
Transcript ID Adipose Adrenal Bladder Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000074936 4.722±0.29 4.751±1.14 6.970±0.64 4.842±0.63 8.280±1.75 1.325±0.17 4.758±0.31 3.124±0.66 4.538±0.77 0.480±0.08 5.609±0.68 9.169±1.34 2.115±0.75
ENSMUST00000138306 N/A N/A N/A N/A 12.255±1.34 N/A N/A N/A N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0006R6 CIL_0006R6_0002 CGP 15:94522688-94581815
CIL_0006R5 CIL_0006R5_0002 CGP 15:94543643-94589889

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000287 IEA magnesium ion binding
GO:0001816 IDA cytokine production
GO:0004674 IEA protein serine/threonine kinase activity
GO:0005149 IPI interleukin-1 receptor binding
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005615 IEA extracellular space
GO:0005737 IEA cytoplasm
GO:0006468 IEA protein phosphorylation
GO:0007254 IEA JNK cascade
GO:0019221 IDA cytokine-mediated signaling pathway
GO:0043123 IEA positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045087 IEA innate immune response
GO:0048661 IEA positive regulation of smooth muscle cell proliferation

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000010657 irak4 interleukin-1 receptor-associated kinase 4 protein_coding Danio_rerio
ENSG00000198001 IRAK4 interleukin-1 receptor-associated kinase 4 protein_coding Homo_sapiens

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