C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: phospholamban
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000198523 PLN 9606 + 6:118548298-118560730 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000357525 PLN-001 118548298-118560730 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000357525
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000357525 3.372±0.00 15.801±0.00 2.574±0.00 0.973±0.00 8.155±3.91 35.497±14.77 494.520±36.55 2.750±2.54 17.339±17.06 10.127±0.20 57.310±4.37 2.501±2.02 0.521±0.64 7.437±6.64

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0005XE CIL_0005XE_0001 CGP 6:117907526-118710075
CIL_000991 CIL_000991_0001 VISTA 6:118257793-118860023
CIL_0005XF CIL_0005XF_0001 CGP 6:118460772-118710075

Gene Ontology
GO IDEvidence TypeGO Description
GO:0002026 IC regulation of the force of heart contraction
GO:0004857 ISS enzyme inhibitor activity
GO:0005246 IEA calcium channel regulator activity
GO:0005515 IPI protein binding
GO:0005739 IDA mitochondrion
GO:0005783 ISS endoplasmic reticulum
GO:0006816 IEA calcium ion transport
GO:0006874 IEA cellular calcium ion homeostasis
GO:0008015 NAS blood circulation
GO:0008016 IMP regulation of heart contraction
GO:0010043 IEA response to zinc ion
GO:0010459 IMP negative regulation of heart rate
GO:0010880 IEA regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
GO:0010881 IEA regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
GO:0016020 IDA:IEA membrane
GO:0016529 IEA sarcoplasmic reticulum
GO:0031982 IEA vesicle
GO:0032780 ISS negative regulation of ATPase activity
GO:0032868 IEA response to insulin
GO:0033574 IEA response to testosterone
GO:0042030 ISS:IEA ATPase inhibitor activity
GO:0042802 ISS identical protein binding
GO:0043086 ISS negative regulation of catalytic activity
GO:0043234 IEA protein complex
GO:0045822 IEA negative regulation of heart contraction
GO:0048471 ISS perinuclear region of cytoplasm
GO:0048738 IEA cardiac muscle tissue development
GO:0051117 ISS ATPase binding
GO:0051260 IEA protein homooligomerization
GO:0051480 IC cytosolic calcium ion homeostasis
GO:0051924 ISS regulation of calcium ion transport
GO:0051926 IDA negative regulation of calcium ion transport
GO:0055119 TAS relaxation of cardiac muscle
GO:0060314 IEA regulation of ryanodine-sensitive calcium-release channel activity
GO:0086004 IC regulation of cardiac muscle cell contraction
GO:0086023 IEA adrenergic receptor signaling pathway involved in heart process
GO:0086036 IC regulation of cardiac muscle cell membrane potential
GO:0086092 IEA regulation of the force of heart contraction by cardiac conduction
GO:0090279 IEA regulation of calcium ion import
GO:0090281 ISS negative regulation of calcium ion import
GO:0090534 IDA calcium ion-transporting ATPase complex
GO:1901020 ISS negative regulation of calcium ion transmembrane transporter activity
GO:1901077 IEA regulation of relaxation of muscle
GO:1901877 ISS negative regulation of calcium ion binding
GO:1901894 IDA regulation of calcium-transporting ATPase activity
GO:1901895 IDA negative regulation of calcium-transporting ATPase activity
GO:1901897 IC regulation of relaxation of cardiac muscle
GO:1902081 ISS negative regulation of calcium ion import into sarcoplasmic reticulum

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSMUSG00000038583 Pln phospholamban protein_coding Mus_musculus

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