C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: SMAD specific E3 ubiquitin protein ligase 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000198742 SMURF1 9606 - 7:99027438-99144100 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000361125 SMURF1-001 99027441-99144100 protein_coding
  ENST00000361368 SMURF1-002 99027438-99144019 protein_coding
  ENST00000472627 SMURF1-003 99057205-99144019 processed_transcript
  ENST00000480055 SMURF1-004 99052212-99081427 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000361125ENST00000361368ENST00000480055
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000361125 2.015±0.00 N/A N/A 2.124±0.64 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000361368 8.516±0.00 4.543±0.00 2.588±0.00 3.415±1.09 4.600±0.20 5.480±2.38 2.549±1.81 6.141±0.00 2.703±0.43 9.818±0.00 2.691±1.09 9.006±3.08 6.245±1.05 19.253±3.34
ENST00000480055 N/A N/A N/A N/A N/A N/A N/A 5.859±0.00 N/A N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0004TP CIL_0004TP_0001 CGP 7:98877933-99144100
CIL_0004TQ CIL_0004TQ_0001 CGP 7:99027438-99207506

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000209 IDA protein polyubiquitination
GO:0004842 IDA:IEA ubiquitin-protein transferase activity
GO:0005515 IPI:IEA protein binding
GO:0005634 IBA nucleus
GO:0005654 TAS nucleoplasm
GO:0005737 IDA cytoplasm
GO:0005829 TAS cytosol
GO:0005886 IDA plasma membrane
GO:0006611 IDA protein export from nucleus
GO:0007179 TAS transforming growth factor beta receptor signaling pathway
GO:0007398 TAS ectoderm development
GO:0016567 IDA protein ubiquitination
GO:0016874 IEA ligase activity
GO:0030154 IDA cell differentiation
GO:0030279 IEA negative regulation of ossification
GO:0030424 IEA axon
GO:0030509 IDA BMP signaling pathway
GO:0030512 IDA negative regulation of transforming growth factor beta receptor signaling pathway
GO:0030514 TAS negative regulation of BMP signaling pathway
GO:0030579 IDA ubiquitin-dependent SMAD protein catabolic process
GO:0032801 IDA receptor catabolic process
GO:0034394 IDA protein localization to cell surface
GO:0042787 IDA protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0043025 IEA neuronal cell body
GO:0043161 IDA proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0048185 NAS activin binding
GO:0070062 IDA extracellular vesicular exosome
GO:0070411 IPI I-SMAD binding
GO:0070412 IPI R-SMAD binding

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000016086 smurf1 SMAD specific E3 ubiquitin protein ligase 1 protein_coding Danio_rerio
ENSMUSG00000038780 Smurf1 SMAD specific E3 ubiquitin protein ligase 1 protein_coding Mus_musculus

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