C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: SMAD specific E3 ubiquitin protein ligase 1
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000361368 SMURF1-002 ENSG00000198742 9606 - 7:99027438-99144019 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000361368
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000361368 8.516±0.00 4.543±0.00 2.588±0.00 3.415±1.09 4.600±0.20 5.480±2.38 2.549±1.81 6.141±0.00 2.703±0.43 9.818±0.00 2.691±1.09 9.006±3.08 6.245±1.05 19.253±3.34

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0004TP CIL_0004TP_0001 CGP 7:98877933-99144100
CIL_0004TQ CIL_0004TQ_0001 CGP 7:99027438-99207506

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000209 IDA protein polyubiquitination
GO:0004842 IDA:IEA ubiquitin-protein transferase activity
GO:0005515 IPI:IEA protein binding
GO:0005634 IBA nucleus
GO:0005654 TAS nucleoplasm
GO:0005737 IDA cytoplasm
GO:0005829 TAS cytosol
GO:0005886 IDA plasma membrane
GO:0006611 IDA protein export from nucleus
GO:0007179 TAS transforming growth factor beta receptor signaling pathway
GO:0007398 TAS ectoderm development
GO:0016567 IDA protein ubiquitination
GO:0016874 IEA ligase activity
GO:0030154 IDA cell differentiation
GO:0030509 IDA BMP signaling pathway
GO:0030512 IDA negative regulation of transforming growth factor beta receptor signaling pathway
GO:0030514 TAS negative regulation of BMP signaling pathway
GO:0030579 IDA ubiquitin-dependent SMAD protein catabolic process
GO:0032801 IDA receptor catabolic process
GO:0034394 IDA protein localization to cell surface
GO:0042787 IDA protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0043161 IDA proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0048185 NAS activin binding
GO:0070062 IDA extracellular vesicular exosome
GO:0070411 IPI I-SMAD binding
GO:0070412 IPI R-SMAD binding

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000085684 Smurf1-001 protein_coding Mus_musculus 0 2935
ENSMUST00000100461 Smurf1-003 protein_coding Mus_musculus 0 2880
ENSMUST00000110677 Smurf1-002 protein_coding Mus_musculus 0 1801
ENSMUST00000126822 Smurf1-004 retained_intron Mus_musculus 0 894

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