C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: topoisomerase (DNA) I
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000198900 TOP1 9606 + 20:41028818-41124487 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000361337 TOP1-001 41028818-41124487 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000361337
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000361337 15.936±0.00 16.667±0.00 2.262±0.00 5.701±3.75 11.109±2.11 12.413±11.05 10.103±0.00 27.022±0.00 7.670±4.34 37.451±0.00 5.127±3.65 27.442±26.10 29.408±16.77 28.371±8.37

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0009AS CIL_0009AS_0001 VISTA 20:40438600-41039972
CIL_0009AT CIL_0009AT_0001 VISTA 20:40443816-41046384
CIL_0008TO CIL_0008TO_0001 VISTA 20:40476967-41078466
CIL_0009AU CIL_0009AU_0001 VISTA 20:40532909-41134985
CIL_0007XA CIL_0007XA_0001 VISTA 20:40544008-41145062
CIL_0008MI CIL_0008MI_0001 VISTA 20:40554707-41155953
CIL_0008QO CIL_0008QO_0001 VISTA 20:40556740-41158918
CIL_0009AV CIL_0009AV_0001 VISTA 20:40645674-41248255
CIL_0004EC CIL_0004EC_0001 CGP 20:41028818-41196787

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000228 IDA nuclear chromosome
GO:0000932 IDA cytoplasmic mRNA processing body
GO:0001046 IDA core promoter sequence-specific DNA binding
GO:0003677 IDA:IEA DNA binding
GO:0003682 IDA chromatin binding
GO:0003917 IDA:IEA DNA topoisomerase type I activity
GO:0003918 IEA DNA topoisomerase type II (ATP-hydrolyzing) activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005654 IDA nucleoplasm
GO:0005694 IEA chromosome
GO:0005730 IDA nucleolus
GO:0005737 IEA cytoplasm
GO:0006200 IEA ATP catabolic process
GO:0006260 IBA DNA replication
GO:0006265 IBA:IEA DNA topological change
GO:0006338 IBA chromatin remodeling
GO:0007059 IBA chromosome segregation
GO:0007623 IEP circadian rhythm
GO:0012501 NAS programmed cell death
GO:0016032 IEA viral process
GO:0016310 NAS phosphorylation
GO:0031298 IBA replication fork protection complex
GO:0032922 IMP circadian regulation of gene expression
GO:0040016 IEA embryonic cleavage
GO:0042493 IEP response to drug
GO:0043204 IEA perikaryon
GO:0044822 IDA poly(A) RNA binding

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000027824 top1mt mitochondrial topoisomerase I protein_coding Danio_rerio
ENSMUSG00000070544 Top1 topoisomerase (DNA) I protein_coding Mus_musculus

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