C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: topoisomerase (DNA) I
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000070544 Top1 10090 + 2:160645888-160722764 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000109468 Top1-001 160645888-160722764 protein_coding
  ENSMUST00000129289 Top1-003 160670133-160684951 retained_intron
  ENSMUST00000133262 Top1-002 160645980-160650107 processed_transcript
  ENSMUST00000150039 Top1-004 160717469-160721384 retained_intron
  ENSMUST00000164510 Top1-006 160702143-160703679 processed_transcript
  ENSMUST00000164694 Top1-005 160685669-160693716 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000109468
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000109468 3.993±1.02 75.295±19.04 10.858±0.46 18.563±3.69 2.247±0.35 3.004±0.91 2.823±0.41 4.137±0.58 13.911±11.99 5.207±0.31 6.734±0.99 26.336±26.39 40.654±22.01 5.018±1.12

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007XC CIL_0007XC_0002 VISTA 2:160082008-160682874
CIL_0008NB CIL_0008NB_0002 VISTA 2:160095708-160696677
CIL_0009AS CIL_0009AS_0002 VISTA 2:160115715-160717232
CIL_0009AT CIL_0009AT_0002 VISTA 2:160121995-160725459
CIL_0008TO CIL_0008TO_0002 VISTA 2:160151305-160752587
CIL_0009AU CIL_0009AU_0002 VISTA 2:160192291-160794448
CIL_0007XA CIL_0007XA_0002 VISTA 2:160203620-160804635
CIL_0008MI CIL_0008MI_0002 VISTA 2:160213670-160814864
CIL_0008QO CIL_0008QO_0002 VISTA 2:160215694-160817266
CIL_0009AV CIL_0009AV_0002 VISTA 2:160278530-160880585
CIL_0004EC CIL_0004EC_0002 CGP 2:160645888-160775760

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000228 IEA nuclear chromosome
GO:0000932 IEA cytoplasmic mRNA processing body
GO:0001046 ISS core promoter sequence-specific DNA binding
GO:0003682 IEA chromatin binding
GO:0003917 IDA DNA topoisomerase type I activity
GO:0003918 IEA DNA topoisomerase type II (ATP-hydrolyzing) activity
GO:0005515 IEA protein binding
GO:0005634 IDA nucleus
GO:0005654 IEA nucleoplasm
GO:0005730 IBA nucleolus
GO:0005737 IDA cytoplasm
GO:0006200 IEA ATP catabolic process
GO:0006260 IMP DNA replication
GO:0006265 IDA DNA topological change
GO:0006338 ISS chromatin remodeling
GO:0007059 IBA chromosome segregation
GO:0007623 IEA circadian rhythm
GO:0031298 IBA replication fork protection complex
GO:0032922 ISS circadian regulation of gene expression
GO:0040016 IMP embryonic cleavage
GO:0042493 IEA response to drug
GO:0043204 IDA perikaryon
GO:0044822 IEA poly(A) RNA binding

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000027824 top1mt mitochondrial topoisomerase I protein_coding Danio_rerio
ENSG00000198900 TOP1 topoisomerase (DNA) I protein_coding Homo_sapiens

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