C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: sphingomyelin synthase 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000198964 SGMS1 9606 - 10:50305586-50625163 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000361543 SGMS1-201 50327278-50344246 protein_coding
  ENST00000361781 SGMS1-003 50305600-50623983 protein_coding
  ENST00000429490 SGMS1-202 50305586-50623977 protein_coding
  ENST00000492601 SGMS1-004 50344136-50418478 processed_transcript
  ENST00000498514 SGMS1-001 50459941-50466932 processed_transcript
  ENST00000602565 SGMS1-002 50342194-50343526 protein_coding
  ENST00000602619 SGMS1-005 50311363-50340676 protein_coding
  ENST00000608287 SGMS1-006 50460673-50625163 processed_transcript
  ENST00000609445 SGMS1-007 50344271-50624986 processed_transcript
  ENST00000619438 SGMS1-203 50341332-50623977 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000361781ENST00000429490ENST00000608287ENST00000609445ENST00000619438
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000361781 3.908±0.00 1.622±0.00 1.316±0.00 3.595±1.12 3.882±1.35 4.875±0.00 3.271±2.45 13.048±0.00 1.648±0.04 9.532±0.00 1.675±0.00 3.058±1.55 3.726±0.53 5.252±0.00
ENST00000429490 N/A 1.554±0.00 N/A 3.057±0.20 N/A 1.538±0.36 0.812±0.00 2.784±0.00 1.240±0.46 2.613±0.00 N/A 1.567±0.00 N/A 1.888±0.00
ENST00000608287 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 8.145±0.00 11.316±0.00 19.135±0.00
ENST00000609445 N/A N/A N/A 10.921±0.00 N/A N/A N/A N/A N/A N/A 2.616±0.00 N/A N/A N/A
ENST00000619438 N/A N/A 1.489±0.00 N/A N/A N/A 1.079±0.00 N/A 3.168±0.00 N/A N/A 2.676±0.11 6.898±0.00 7.190±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0000IG CIL_0000IG_0001 CGP 10:50182778-50625163

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000138 IDA Golgi trans cisterna
GO:0000139 TAS Golgi membrane
GO:0003824 IEA catalytic activity
GO:0005515 IEA protein binding
GO:0005634 TAS nucleus
GO:0005783 TAS endoplasmic reticulum
GO:0005886 TAS plasma membrane
GO:0006665 TAS sphingolipid metabolic process
GO:0006686 IDA sphingomyelin biosynthetic process
GO:0006915 IEA apoptotic process
GO:0006954 IEA inflammatory response
GO:0010628 IEA positive regulation of gene expression
GO:0016020 IDA:IEA membrane
GO:0016021 IEA integral component of membrane
GO:0016049 IDA cell growth
GO:0016301 IEA kinase activity
GO:0016310 IEA phosphorylation
GO:0030148 TAS sphingolipid biosynthetic process
GO:0030173 IDA integral component of Golgi membrane
GO:0033188 IMP sphingomyelin synthase activity
GO:0044281 TAS small molecule metabolic process
GO:0047493 IDA ceramide cholinephosphotransferase activity
GO:0071222 IEA cellular response to lipopolysaccharide
GO:0071356 IEA cellular response to tumor necrosis factor
GO:2001237 IEA negative regulation of extrinsic apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000029621 sgms1 sphingomyelin synthase 1 protein_coding Danio_rerio
ENSDARG00000057053 SGMS1 (2 of 2) sphingomyelin synthase 1 protein_coding Danio_rerio
ENSMUSG00000040451 Sgms1 sphingomyelin synthase 1 protein_coding Mus_musculus

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