C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: sphingomyelin synthase 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000040451 Sgms1 10090 - 19:32122727-32389714 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000099514 Sgms1-001 32122727-32388512 protein_coding
  ENSMUST00000124012 Sgms1-005 32158256-32389714 retained_intron
  ENSMUST00000124483 Sgms1-006 32220587-32289579 retained_intron
  ENSMUST00000126332 Sgms1-011 32223318-32238826 retained_intron
  ENSMUST00000131768 Sgms1-010 32160299-32276926 processed_transcript
  ENSMUST00000134415 Sgms1-007 32124147-32160223 nonsense_mediated_decay
  ENSMUST00000141252 Sgms1-008 32289279-32388463 retained_intron
  ENSMUST00000141655 Sgms1-009 32160170-32323229 processed_transcript
  ENSMUST00000142618 Sgms1-002 32122730-32349316 protein_coding
  ENSMUST00000149107 Sgms1-012 32160158-32238812 processed_transcript
  ENSMUST00000149934 Sgms1-013 32218757-32248009 processed_transcript
  ENSMUST00000151289 Sgms1-004 32123479-32210990 protein_coding
  ENSMUST00000151822 Sgms1-014 32160061-32196428 protein_coding
  ENSMUST00000152340 Sgms1-003 32124145-32276952 nonsense_mediated_decay

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000099514ENSMUST00000134415ENSMUST00000141252ENSMUST00000141655ENSMUST00000151289ENSMUST00000152340
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000099514 4.381±0.63 3.119±0.39 5.486±0.36 2.266±0.25 1.908±0.28 2.963±0.89 3.717±1.07 3.904±0.75 2.924±1.46 4.607±0.46 7.515±1.37 6.143±2.23 5.052±2.14 N/A
ENSMUST00000134415 4.054±0.00 7.915±1.48 N/A 6.943±0.00 4.335±0.66 5.936±1.69 N/A 4.105±0.00 2.336±1.15 N/A N/A 12.671±4.56 8.540±4.48 54.907±12.72
ENSMUST00000141252 N/A 18.877±5.15 N/A N/A 8.479±0.99 6.922±1.76 N/A N/A 1.849±0.00 N/A N/A 15.136±3.73 N/A N/A
ENSMUST00000141655 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 26.908±0.00 N/A 260.444±0.00
ENSMUST00000151289 6.125±2.32 5.848±1.47 8.269±0.37 2.149±1.08 6.291±3.70 4.241±1.25 7.128±1.83 7.904±1.14 4.082±2.52 15.940±5.81 5.606±1.32 6.826±2.61 10.834±5.21 20.509±0.00
ENSMUST00000152340 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 35.043±15.50

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0000IG CIL_0000IG_0002 CGP 19:31984654-32389714

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000138 ISA Golgi trans cisterna
GO:0005634 TAS nucleus
GO:0005783 TAS endoplasmic reticulum
GO:0005886 TAS plasma membrane
GO:0006686 ISS sphingomyelin biosynthetic process
GO:0006915 IEA apoptotic process
GO:0006954 IEA inflammatory response
GO:0010628 IEA positive regulation of gene expression
GO:0016049 IDA cell growth
GO:0016301 IEA kinase activity
GO:0016310 IEA phosphorylation
GO:0030173 ISS integral component of Golgi membrane
GO:0033188 IMP sphingomyelin synthase activity
GO:0047493 ISS ceramide cholinephosphotransferase activity
GO:0071222 IEA cellular response to lipopolysaccharide
GO:0071356 IEA cellular response to tumor necrosis factor
GO:2001237 IDA negative regulation of extrinsic apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000029621 sgms1 sphingomyelin synthase 1 protein_coding Danio_rerio
ENSDARG00000057053 SGMS1 (2 of 2) sphingomyelin synthase 1 protein_coding Danio_rerio
ENSG00000198964 SGMS1 sphingomyelin synthase 1 protein_coding Homo_sapiens

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