C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: major histocompatibility complex, class I, C
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000204525 HLA-C 9606 - 6:31268749-31357158 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000376228 HLA-C-001 31268749-31272086 protein_coding
  ENST00000376237 HLA-C-006 31268749-31272105 nonsense_mediated_decay
  ENST00000383329 HLA-C-002 31268749-31272086 protein_coding
  ENST00000415537 HLA-C-007 31270214-31272069 protein_coding
  ENST00000466892 HLA-C-011 31268749-31269666 retained_intron
  ENST00000470363 HLA-C-010 31268749-31270422 retained_intron
  ENST00000484378 HLA-C-012 31271099-31272090 retained_intron
  ENST00000487245 HLA-C-005 31268749-31272050 retained_intron
  ENST00000495835 HLA-C-008 31270221-31272130 retained_intron
  ENST00000620806 HLA-C-201 31269339-31357158 protein_coding

Homo sapiens EnsemblGRCh38

Genome
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Genes
Gene structures from Ensembl
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Transcripts
Structures from Ensembl
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Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000376228ENST00000376237ENST00000415537ENST00000495835
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000376228 558.774±0.00 379.277±0.00 N/A 65.456±55.17 220.811±181.19 181.866±160.37 74.318±59.85 313.910±0.00 81.921±59.32 893.073±835.41 N/A 327.959±200.32 305.400±193.20 268.216±0.00
ENST00000376237 N/A 265.696±0.00 5.107±0.00 N/A N/A N/A N/A 36.107±0.00 N/A N/A 67.750±0.00 N/A N/A N/A
ENST00000415537 N/A N/A 13.837±0.00 N/A N/A 40.970±0.00 N/A N/A N/A N/A 23.783±0.00 N/A N/A N/A
ENST00000495835 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 45.049±0.00 N/A 56.456±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_000420 CIL_000420_0001 CGP 6:31268749-31357188

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000139 TAS Golgi membrane
GO:0001916 IEA positive regulation of T cell mediated cytotoxicity
GO:0002474 TAS antigen processing and presentation of peptide antigen via MHC class I
GO:0002479 TAS antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0002480 TAS antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent
GO:0005515 IEA protein binding
GO:0005783 ISS endoplasmic reticulum
GO:0005794 ISS Golgi apparatus
GO:0005886 TAS plasma membrane
GO:0006955 IEA immune response
GO:0009986 IDA cell surface
GO:0012507 TAS ER to Golgi transport vesicle membrane
GO:0016020 IEA membrane
GO:0016021 IEA integral component of membrane
GO:0016032 IEA viral process
GO:0019221 TAS cytokine-mediated signaling pathway
GO:0019882 IEA antigen processing and presentation
GO:0030670 TAS phagocytic vesicle membrane
GO:0031901 TAS early endosome membrane
GO:0042590 TAS antigen processing and presentation of exogenous peptide antigen via MHC class I
GO:0042605 ISS peptide antigen binding
GO:0042612 ISS:IEA MHC class I protein complex
GO:0050776 TAS regulation of immune response
GO:0060333 TAS interferon-gamma-mediated signaling pathway
GO:0060337 TAS type I interferon signaling pathway
GO:0070062 IDA extracellular vesicular exosome
GO:0071556 TAS integral component of lumenal side of endoplasmic reticulum membrane

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSMUSG00000037334 H2-M1 histocompatibility 2, M region locus 1 protein_coding Mus_musculus
ENSMUSG00000037537 H2-M11 histocompatibility 2, M region locus 11 protein_coding Mus_musculus
ENSMUSG00000067201 H2-M9 histocompatibility 2, M region locus 9 protein_coding Mus_musculus

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