C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: major histocompatibility complex, class I, F
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000204642 HLA-F 9606 + 6:29722775-29738528 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000259951 HLA-F-003 29723408-29727296 protein_coding
  ENST00000334668 HLA-F-202 29723340-29726525 protein_coding
  ENST00000376861 HLA-F-001 29722775-29726526 protein_coding
  ENST00000414333 HLA-F-004 29723279-29724231 protein_coding
  ENST00000429294 HLA-F-006 29724039-29726526 protein_coding
  ENST00000434407 HLA-F-002 29723464-29726526 protein_coding
  ENST00000444621 HLA-F-005 29725534-29727296 protein_coding
  ENST00000462777 HLA-F-007 29723392-29724415 processed_transcript
  ENST00000465459 HLA-F-014 29725054-29738528 processed_transcript
  ENST00000475996 HLA-F-013 29725454-29729351 processed_transcript
  ENST00000482257 HLA-F-009 29723434-29725087 processed_transcript
  ENST00000484704 HLA-F-012 29724157-29726526 processed_transcript
  ENST00000485513 HLA-F-011 29723940-29725299 processed_transcript
  ENST00000486194 HLA-F-010 29723504-29724352 processed_transcript
  ENST00000489502 HLA-F-008 29723427-29726526 processed_transcript
  ENST00000606273 HLA-F-015 29724417-29726528 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000259951ENST00000334668ENST00000429294ENST00000434407ENST00000465459ENST00000482257ENST00000484704ENST00000485513ENST00000489502ENST00000606273
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000259951 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 3.405±0.00 N/A N/A
ENST00000334668 N/A N/A N/A N/A N/A N/A 2.851±0.00 N/A N/A N/A N/A 9.203±5.40 10.361±4.10 N/A
ENST00000429294 31.399±0.00 74.507±0.00 N/A 7.671±0.00 11.915±3.47 14.930±5.23 21.053±0.00 17.944±7.94 5.734±0.54 37.058±28.73 3.151±0.65 18.237±7.40 12.308±7.21 20.809±0.00
ENST00000434407 N/A N/A 1.440±0.00 N/A N/A N/A N/A N/A N/A 8.249±0.00 N/A 55.790±0.00 12.300±0.00 5.358±0.00
ENST00000465459 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 23.635±0.00 N/A N/A
ENST00000482257 N/A N/A N/A N/A N/A N/A N/A N/A 9.007±0.51 N/A N/A 28.527±14.05 12.589±0.00 N/A
ENST00000484704 N/A N/A N/A N/A N/A N/A N/A N/A N/A 41.464±0.00 N/A 11.924±2.91 N/A 2.661±0.00
ENST00000485513 39.863±0.00 57.991±0.00 3.610±0.00 5.350±3.15 17.486±7.48 22.787±0.00 23.979±0.00 N/A N/A 46.575±37.73 N/A 33.193±11.59 8.133±0.00 8.147±0.00
ENST00000489502 68.197±0.00 N/A 3.081±0.00 N/A 16.998±0.84 13.532±0.00 5.803±0.00 35.599±0.00 N/A 57.989±40.45 5.290±0.57 32.665±16.31 9.507±0.00 8.519±0.00
ENST00000606273 N/A N/A N/A 3.095±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_000420 CIL_000420_0003 CGP 6:29722775-29831125

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000139 TAS Golgi membrane
GO:0001916 IEA positive regulation of T cell mediated cytotoxicity
GO:0002474 IEA:TAS antigen processing and presentation of peptide antigen via MHC class I
GO:0002479 TAS antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0002480 TAS antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent
GO:0005515 IEA protein binding
GO:0005783 IDA endoplasmic reticulum
GO:0005886 TAS plasma membrane
GO:0006955 IEA immune response
GO:0012507 TAS ER to Golgi transport vesicle membrane
GO:0016020 IDA membrane
GO:0019221 TAS cytokine-mediated signaling pathway
GO:0019882 IEA antigen processing and presentation
GO:0030670 TAS phagocytic vesicle membrane
GO:0031901 TAS early endosome membrane
GO:0042590 TAS antigen processing and presentation of exogenous peptide antigen via MHC class I
GO:0042605 IEA peptide antigen binding
GO:0042612 IEA MHC class I protein complex
GO:0046978 IPI TAP1 binding
GO:0046979 IPI TAP2 binding
GO:0050776 TAS regulation of immune response
GO:0060333 TAS interferon-gamma-mediated signaling pathway
GO:0060337 TAS type I interferon signaling pathway
GO:0071556 TAS integral component of lumenal side of endoplasmic reticulum membrane

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSMUSG00000037334 H2-M1 histocompatibility 2, M region locus 1 protein_coding Mus_musculus
ENSMUSG00000037537 H2-M11 histocompatibility 2, M region locus 11 protein_coding Mus_musculus
ENSMUSG00000067201 H2-M9 histocompatibility 2, M region locus 9 protein_coding Mus_musculus

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