C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: deiodinase, iodothyronine, type II
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000211448 DIO2 9606 - 14:80197527-80387757 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000422005 DIO2-201 80197527-80211521 protein_coding
  ENST00000438257 DIO2-002 80197530-80211627 protein_coding
  ENST00000553594 DIO2-007 80211455-80315876 protein_coding
  ENST00000553968 DIO2-009 80211454-80212178 protein_coding
  ENST00000554188 DIO2-006 80211309-80387757 protein_coding
  ENST00000555750 DIO2-003 80202598-80211500 protein_coding
  ENST00000555844 DIO2-005 80202819-80211314 nonsense_mediated_decay
  ENST00000556384 DIO2-008 80278429-80315838 processed_transcript
  ENST00000556811 DIO2-004 80202503-80211314 protein_coding
  ENST00000557010 DIO2-001 80197530-80231054 protein_coding
  ENST00000557125 DIO2-010 80202618-80211472 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000422005ENST00000438257ENST00000553968ENST00000555844ENST00000556811ENST00000557010ENST00000557125
Transcript ID Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000422005 0.187±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000438257 0.428±0.00 N/A 5.257±3.69 4.906±0.00 0.300±0.00 0.939±0.26 0.180±0.17 0.271±0.00 0.216±0.07 0.264±0.00 2.342±2.19 2.535±1.44 1.069±0.00
ENST00000553968 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 9.898±0.00 N/A
ENST00000555844 N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.997±0.00 N/A N/A N/A
ENST00000556811 N/A 0.316±0.00 N/A N/A N/A N/A N/A N/A N/A N/A 0.163±0.00 N/A N/A
ENST00000557010 N/A N/A N/A 0.255±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000557125 N/A N/A N/A N/A N/A N/A 0.877±0.00 N/A 1.012±0.00 N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0004U0 CIL_0004U0_0001 CGP 14:78242391-80387757
CIL_0004TZ CIL_0004TZ_0001 CGP 14:80197527-80959517

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001514 NAS selenocysteine incorporation
GO:0004800 IEA thyroxine 5'-deiodinase activity
GO:0005886 TAS plasma membrane
GO:0006590 TAS thyroid hormone generation
GO:0008430 IC selenium binding
GO:0016020 IC membrane
GO:0016021 IEA integral component of membrane
GO:0016209 IEA antioxidant activity
GO:0016491 IEA oxidoreductase activity
GO:0031625 IPI ubiquitin protein ligase binding
GO:0034641 TAS cellular nitrogen compound metabolic process
GO:0042403 IDA thyroid hormone metabolic process
GO:0042404 IEA thyroid hormone catabolic process
GO:0042446 IEA hormone biosynthetic process
GO:0044281 TAS small molecule metabolic process
GO:0055114 IEA oxidation-reduction process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000094857 dio2 deiodinase, iodothyronine, type II protein_coding Danio_rerio
ENSMUSG00000007682 Dio2 deiodinase, iodothyronine, type II protein_coding Mus_musculus

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