C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: major histocompatibility complex, class I, B
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000234745 HLA-B 9606 - 6:31353872-31357188 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000412585 HLA-B-001 31353872-31357187 protein_coding
  ENST00000434333 HLA-B-003 31355507-31357188 protein_coding
  ENST00000463574 HLA-B-005 31355122-31355802 retained_intron
  ENST00000474381 HLA-B-009 31355522-31356905 retained_intron
  ENST00000481849 HLA-B-008 31353872-31354806 retained_intron
  ENST00000497377 HLA-B-007 31353872-31355076 retained_intron
  ENST00000498007 HLA-B-002 31355391-31357179 retained_intron

Homo sapiens EnsemblGRCh38

Genome
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Genes
Gene structures from Ensembl
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Transcripts
Structures from Ensembl
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Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000412585ENST00000463574
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000412585 994.668±0.00 1156.520±0.00 13.029±0.00 58.178±43.90 389.471±321.34 268.327±218.29 140.305±117.33 283.761±226.11 106.181±63.68 1419.107±1352.12 80.828±52.77 486.000±258.34 598.333±87.69 208.164±142.33
ENST00000463574 N/A N/A 24.731±0.00 16.236±0.00 148.163±0.00 112.619±0.00 25.222±0.00 78.265±0.00 54.999±0.00 216.835±0.00 N/A 1198.202±1019.14 962.281±0.00 132.281±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_000420 CIL_000420_0001 CGP 6:31268749-31357188

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000139 TAS Golgi membrane
GO:0001916 IEA positive regulation of T cell mediated cytotoxicity
GO:0002474 IEA:TAS antigen processing and presentation of peptide antigen via MHC class I
GO:0002479 TAS antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0002480 TAS antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent
GO:0002667 IMP regulation of T cell anergy
GO:0005102 IPI receptor binding
GO:0005515 IEA protein binding
GO:0005783 ISS:IDA endoplasmic reticulum
GO:0005794 ISS:IDA Golgi apparatus
GO:0005886 TAS plasma membrane
GO:0005887 NAS integral component of plasma membrane
GO:0006955 IEA:NAS immune response
GO:0009986 ISS cell surface
GO:0012507 TAS ER to Golgi transport vesicle membrane
GO:0016020 IDA:IEA membrane
GO:0016021 IEA integral component of membrane
GO:0016032 IEA viral process
GO:0019221 TAS cytokine-mediated signaling pathway
GO:0019882 IEA antigen processing and presentation
GO:0030670 TAS phagocytic vesicle membrane
GO:0031901 TAS early endosome membrane
GO:0032655 IMP regulation of interleukin-12 production
GO:0032675 IMP regulation of interleukin-6 production
GO:0042270 IDA protection from natural killer cell mediated cytotoxicity
GO:0042590 TAS antigen processing and presentation of exogenous peptide antigen via MHC class I
GO:0042605 ISS peptide antigen binding
GO:0042612 ISS:IEA MHC class I protein complex
GO:0050776 TAS regulation of immune response
GO:0060333 TAS interferon-gamma-mediated signaling pathway
GO:0060337 TAS type I interferon signaling pathway
GO:0070062 IDA extracellular vesicular exosome
GO:0071556 TAS integral component of lumenal side of endoplasmic reticulum membrane
GO:2001198 IMP regulation of dendritic cell differentiation

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSMUSG00000037334 H2-M1 histocompatibility 2, M region locus 1 protein_coding Mus_musculus
ENSMUSG00000037537 H2-M11 histocompatibility 2, M region locus 11 protein_coding Mus_musculus
ENSMUSG00000067201 H2-M9 histocompatibility 2, M region locus 9 protein_coding Mus_musculus

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