C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: major histocompatibility complex, class II, DM beta
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000242574 HLA-DMB 9606 - 6:32934629-32941070 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000414017 HLA-DMB-006 32934629-32938688 protein_coding
  ENST00000418107 HLA-DMB-001 32934629-32941070 protein_coding
  ENST00000438510 HLA-DMB-007 32934629-32937439 protein_coding
  ENST00000477537 HLA-DMB-004 32934629-32936901 retained_intron
  ENST00000487996 HLA-DMB-005 32934629-32936886 retained_intron
  ENST00000498020 HLA-DMB-003 32934629-32940984 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; BreastHeartLiverLungOvaryPlacentaENST00000418107
Transcript ID Breast Heart Liver Lung Ovary Placenta
ENST00000418107 33.132±0.00 6.143±0.00 11.400±0.00 54.058±0.00 18.980±0.00 40.277±1.64

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0001PK CIL_0001PK_0004 CGP 6:32934629-32953122

Gene Ontology
GO IDEvidence TypeGO Description
GO:0002399 IMP MHC class II protein complex assembly
GO:0002503 IDA peptide antigen assembly with MHC class II protein complex
GO:0005515 IEA protein binding
GO:0005765 TAS lysosomal membrane
GO:0005768 IEA endosome
GO:0006955 IEA immune response
GO:0016020 IEA membrane
GO:0016021 IEA integral component of membrane
GO:0019882 IEA antigen processing and presentation
GO:0019886 IMP antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0023026 IDA MHC class II protein complex binding
GO:0042102 IMP positive regulation of T cell proliferation
GO:0042613 IDA:IEA MHC class II protein complex
GO:2001190 IMP positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000041705 si:busm1-228j01.6 si:busm1-228j01.6 protein_coding Danio_rerio
ENSDARG00000053738 si:dkey-33b17.3 si:dkey-33b17.3 protein_coding Danio_rerio
ENSDARG00000054921 wu:fd58b11 wu:fd58b11 protein_coding Danio_rerio
ENSDARG00000055447 si:busm1-194e12.12 si:busm1-194e12.12 protein_coding Danio_rerio
ENSDARG00000056330 mhc2dbb major histocompatibility complex class II DBB gene protein_coding Danio_rerio
ENSDARG00000074510 si:busm1-104n07.3 si:busm1-104n07.3 protein_coding Danio_rerio
ENSDARG00000076307 si:zfos-2070c2.3 si:zfos-2070c2.3 protein_coding Danio_rerio
ENSDARG00000079105 mhc2dab major histocompatibility complex class II DAB gene protein_coding Danio_rerio
ENSDARG00000088872 si:busm1-228j01.4 si:busm1-228j01.4 protein_coding Danio_rerio
ENSDARG00000093706 si:dkey-33b17.3 si:dkey-33b17.3 protein_coding Danio_rerio
ENSMUSG00000037548 H2-DMb2 histocompatibility 2, class II, locus Mb2 protein_coding Mus_musculus
ENSMUSG00000079547 H2-DMb1 histocompatibility 2, class II, locus Mb1 protein_coding Mus_musculus

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