C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: lymphocyte protein tyrosine kinase
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000102596 Lck-001 ENSMUSG00000000409 10090 - 4:129548349-129573641 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaENSMUST00000102596
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta
ENSMUST00000102596 1.688±0.92 0.279±0.00 1.067±0.33 0.159±0.00 30.916±14.32 1.663±0.90 0.586±0.24 2.970±2.19 0.545±0.33 3.821±0.64 1.745±1.74 0.743±0.30 0.452±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008AA CIL_0008AA_0002 VISTA 4:129413466-130014337

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000242 ISS pericentriolar material
GO:0004713 IMP:ISS protein tyrosine kinase activity
GO:0004715 IEA non-membrane spanning protein tyrosine kinase activity
GO:0004722 ISS protein serine/threonine phosphatase activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005829 TAS cytosol
GO:0005911 IDA cell-cell junction
GO:0006468 IDA protein phosphorylation
GO:0006882 ISS cellular zinc ion homeostasis
GO:0006919 ISS activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007166 IDA cell surface receptor signaling pathway
GO:0010628 IDA positive regulation of gene expression
GO:0016311 ISS dephosphorylation
GO:0018108 IDA peptidyl-tyrosine phosphorylation
GO:0030217 ISS T cell differentiation
GO:0042169 ISS SH2 domain binding
GO:0042493 ISS response to drug
GO:0042523 IDA positive regulation of tyrosine phosphorylation of Stat5 protein
GO:0045121 ISS membrane raft
GO:0045588 IMP positive regulation of gamma-delta T cell differentiation
GO:0046777 IDA protein autophosphorylation
GO:0050853 IDA B cell receptor signaling pathway
GO:0050856 IDA regulation of T cell receptor signaling pathway
GO:0050870 ISS positive regulation of T cell activation
GO:0051209 IDA release of sequestered calcium ion into cytosol
GO:2001244 ISS positive regulation of intrinsic apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSDART00000020099 blk-201 protein_coding Danio_rerio 0 209
ENSDART00000138028 blk-001 protein_coding Danio_rerio 0 209
ENST00000333070 LCK-004 protein_coding Homo_sapiens 0 1182
ENST00000336890 LCK-001 protein_coding Homo_sapiens 0 2036
ENST00000373557 LCK-010 protein_coding Homo_sapiens 0 869
ENST00000373564 LCK-201 protein_coding Homo_sapiens 0 959
ENST00000374003 FGR-002 protein_coding Homo_sapiens 0 252
ENST00000374004 FGR-004 protein_coding Homo_sapiens 0 252
ENST00000374005 FGR-001 protein_coding Homo_sapiens 0 252
ENST00000399173 FGR-201 protein_coding Homo_sapiens 0 252
ENST00000469765 LCK-007 retained_intron Homo_sapiens 0 1312
ENST00000469956 LCK-003 retained_intron Homo_sapiens 0 682
ENST00000495610 LCK-006 protein_coding Homo_sapiens 0 846
ENST00000619559 LCK-202 protein_coding Homo_sapiens 0 1906

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