C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: lymphocyte protein tyrosine kinase
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000167288 Lck-201 ENSMUSG00000000409 10090 - 4:129548344-129558372 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBreastColonHeartKidneyLiverMusclePlacentaENSMUST00000167288
Transcript ID Adipose Adrenal Breast Colon Heart Kidney Liver Muscle Placenta
ENSMUST00000167288 1.268±0.00 0.827±0.07 13.320±0.00 0.663±0.00 0.125±0.08 0.279±0.00 0.847±0.45 0.043±0.01 0.263±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008AA CIL_0008AA_0002 VISTA 4:129413466-130014337

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000242 ISS pericentriolar material
GO:0001772 IEA immunological synapse
GO:0001948 IEA glycoprotein binding
GO:0003823 IEA antigen binding
GO:0004713 IMP:ISS protein tyrosine kinase activity
GO:0004715 IEA non-membrane spanning protein tyrosine kinase activity
GO:0004722 ISS protein serine/threonine phosphatase activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005829 TAS cytosol
GO:0005886 IEA plasma membrane
GO:0005911 IDA cell-cell junction
GO:0006468 IDA protein phosphorylation
GO:0006882 ISS cellular zinc ion homeostasis
GO:0006915 IEA apoptotic process
GO:0006919 ISS activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007166 IDA cell surface receptor signaling pathway
GO:0007568 IEA aging
GO:0008022 IEA protein C-terminus binding
GO:0009612 IEA response to mechanical stimulus
GO:0010038 IEA response to metal ion
GO:0010043 IEA response to zinc ion
GO:0010628 IDA positive regulation of gene expression
GO:0016311 ISS dephosphorylation
GO:0018108 IDA peptidyl-tyrosine phosphorylation
GO:0019901 IEA protein kinase binding
GO:0019903 IEA protein phosphatase binding
GO:0030139 IEA endocytic vesicle
GO:0030217 ISS T cell differentiation
GO:0032403 IEA protein complex binding
GO:0042169 ISS SH2 domain binding
GO:0042493 ISS response to drug
GO:0042523 IDA positive regulation of tyrosine phosphorylation of Stat5 protein
GO:0042542 IEA response to hydrogen peroxide
GO:0042609 IEA CD4 receptor binding
GO:0042610 IEA CD8 receptor binding
GO:0042802 IEA identical protein binding
GO:0043548 IEA phosphatidylinositol 3-kinase binding
GO:0045121 ISS membrane raft
GO:0045588 IMP positive regulation of gamma-delta T cell differentiation
GO:0046777 IDA protein autophosphorylation
GO:0050853 IDA B cell receptor signaling pathway
GO:0050856 IDA regulation of T cell receptor signaling pathway
GO:0050870 ISS positive regulation of T cell activation
GO:0051117 IEA ATPase binding
GO:0051209 IDA release of sequestered calcium ion into cytosol
GO:0070062 IEA extracellular vesicular exosome
GO:0070474 IEA positive regulation of uterine smooth muscle contraction
GO:2001244 ISS positive regulation of intrinsic apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSDART00000020099 blk-201 protein_coding Danio_rerio 0 209
ENSDART00000138028 blk-001 protein_coding Danio_rerio 0 209
ENST00000333070 LCK-004 protein_coding Homo_sapiens 0 1184
ENST00000336890 LCK-001 protein_coding Homo_sapiens 0 1903
ENST00000373557 LCK-010 protein_coding Homo_sapiens 0 867
ENST00000373564 LCK-201 protein_coding Homo_sapiens 0 959
ENST00000374003 FGR-002 protein_coding Homo_sapiens 0 252
ENST00000374004 FGR-004 protein_coding Homo_sapiens 0 252
ENST00000374005 FGR-001 protein_coding Homo_sapiens 0 252
ENST00000399173 FGR-201 protein_coding Homo_sapiens 0 252
ENST00000469765 LCK-007 retained_intron Homo_sapiens 0 1262
ENST00000469956 LCK-003 retained_intron Homo_sapiens 0 682
ENST00000495610 LCK-006 protein_coding Homo_sapiens 0 756
ENST00000619559 LCK-202 protein_coding Homo_sapiens 0 1908

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