C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: signal transducer and activator of transcription 3
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000004040 Stat3 10090 - 11:100885098-100939540 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000092671 Stat3-010 100888236-100939380 protein_coding
  ENSMUST00000103114 Stat3-002 100885098-100939404 protein_coding
  ENSMUST00000127638 Stat3-001 100886810-100939540 protein_coding
  ENSMUST00000130686 Stat3-004 100905656-100908224 retained_intron
  ENSMUST00000137093 Stat3-014 100888222-100890312 retained_intron
  ENSMUST00000137367 Stat3-007 100893524-100894433 retained_intron
  ENSMUST00000138438 Stat3-011 100888681-100939479 protein_coding
  ENSMUST00000146971 Stat3-006 100894490-100898528 retained_intron
  ENSMUST00000151544 Stat3-008 100894488-100895122 retained_intron
  ENSMUST00000152601 Stat3-013 100889478-100893743 retained_intron
  ENSMUST00000152623 Stat3-012 100905080-100905846 retained_intron
  ENSMUST00000154170 Stat3-005 100902737-100905411 retained_intron
  ENSMUST00000155972 Stat3-009 100893029-100893802 retained_intron
  ENSMUST00000156645 Stat3-003 100893971-100899307 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000092671ENSMUST00000127638ENSMUST00000138438ENSMUST00000155972
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000092671 N/A N/A N/A 6.556±0.00 N/A N/A N/A N/A N/A N/A N/A 20.694±0.00 11.901±1.98 5.873±0.00
ENSMUST00000127638 50.506±9.86 33.126±4.60 37.966±2.78 7.446±2.50 66.547±3.28 53.748±7.17 40.185±2.67 23.558±2.54 22.982±7.11 73.355±2.03 6.506±2.01 54.159±16.79 18.338±8.30 8.311±3.74
ENSMUST00000138438 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 8.995±0.00 N/A
ENSMUST00000155972 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 73.444±0.00 N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0006I7 CIL_0006I7_0002 CGP 11:100780731-100885169
CIL_0006IK CIL_0006IK_0002 CGP 11:100859351-100939540
CIL_00046I CIL_00046I_0002 CGP 11:100885098-100970887

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000981 IDA sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001103 IEA RNA polymerase II repressing transcription factor binding
GO:0001659 IMP temperature homeostasis
GO:0001754 IMP eye photoreceptor cell differentiation
GO:0003677 IDA DNA binding
GO:0004871 IEA signal transducer activity
GO:0004879 IEA ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0005509 IEA calcium ion binding
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005654 TAS nucleoplasm
GO:0005737 IDA cytoplasm
GO:0005743 IEA mitochondrial inner membrane
GO:0005829 TAS cytosol
GO:0005886 IDA plasma membrane
GO:0006355 NAS regulation of transcription, DNA-templated
GO:0006366 IDA transcription from RNA polymerase II promoter
GO:0006606 ISS protein import into nucleus
GO:0006953 IEA acute-phase response
GO:0007165 IEA signal transduction
GO:0007259 TAS JAK-STAT cascade
GO:0008134 ISS transcription factor binding
GO:0008283 IDA cell proliferation
GO:0008285 IGI negative regulation of cell proliferation
GO:0010033 IEA response to organic substance
GO:0014070 IEA response to organic cyclic compound
GO:0016310 IDA phosphorylation
GO:0019221 NAS cytokine-mediated signaling pathway
GO:0019827 IMP stem cell maintenance
GO:0019901 IPI protein kinase binding
GO:0019903 IEA protein phosphatase binding
GO:0019953 IMP sexual reproduction
GO:0030522 IEA intracellular receptor signaling pathway
GO:0031730 IEA CCR5 chemokine receptor binding
GO:0032355 IEA response to estradiol
GO:0032870 IEA cellular response to hormone stimulus
GO:0034097 IEA response to cytokine
GO:0035259 IEA glucocorticoid receptor binding
GO:0040014 IMP regulation of multicellular organism growth
GO:0042493 IEA response to drug
GO:0042593 IMP glucose homeostasis
GO:0042755 IMP eating behavior
GO:0043434 IEA response to peptide hormone
GO:0043565 IDA sequence-specific DNA binding
GO:0044212 IEA transcription regulatory region DNA binding
GO:0045471 IEA response to ethanol
GO:0045747 IMP positive regulation of Notch signaling pathway
GO:0045820 IMP negative regulation of glycolytic process
GO:0045893 IDA positive regulation of transcription, DNA-templated
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0046983 IPI protein dimerization activity
GO:0048708 IMP astrocyte differentiation
GO:0060019 IMP radial glial cell differentiation
GO:0060396 IEA growth hormone receptor signaling pathway
GO:0060397 IDA JAK-STAT cascade involved in growth hormone signaling pathway
GO:0060548 IEA negative regulation of cell death
GO:0070102 ISS interleukin-6-mediated signaling pathway
GO:2001223 IGI negative regulation of neuron migration

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000022712 stat3 signal transduction and activation of transcription 3 protein_coding Danio_rerio
ENSG00000168610 STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) protein_coding Homo_sapiens

Loading