C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: signal transducer and activator of transcription 3 (acute-phase response factor)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000168610 STAT3 9606 - 17:42313324-42388568 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000264657 STAT3-001 42313324-42388568 protein_coding
  ENST00000389272 STAT3-013 42315468-42388431 protein_coding
  ENST00000404395 STAT3-002 42315559-42388414 protein_coding
  ENST00000462269 STAT3-006 42315597-42317562 retained_intron
  ENST00000462286 STAT3-014 42314872-42316853 retained_intron
  ENST00000471989 STAT3-005 42323035-42325061 retained_intron
  ENST00000478276 STAT3-003 42329658-42331538 retained_intron
  ENST00000491272 STAT3-007 42315511-42317223 retained_intron
  ENST00000498330 STAT3-004 42323064-42325157 retained_intron
  ENST00000585360 STAT3-017 42345414-42348516 retained_intron
  ENST00000585517 STAT3-012 42314854-42388439 protein_coding
  ENST00000588065 STAT3-016 42346596-42388454 protein_coding
  ENST00000588969 STAT3-011 42315491-42388482 protein_coding
  ENST00000590776 STAT3-015 42386939-42388421 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000264657ENST00000389272ENST00000404395ENST00000585517ENST00000588969
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000264657 32.917±0.00 37.606±0.00 2.716±0.00 5.322±3.17 11.402±3.47 14.799±9.77 38.503±0.00 5.035±0.00 10.179±2.76 27.947±19.09 24.772±21.55 13.702±8.90 11.475±1.04 8.155±0.96
ENST00000389272 N/A N/A N/A 1.299±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000404395 N/A N/A N/A 4.383±3.23 N/A N/A N/A N/A N/A N/A N/A N/A N/A 4.739±0.00
ENST00000585517 N/A N/A 2.392±0.00 3.371±2.44 7.752±0.00 N/A 1.850±0.00 4.577±0.00 4.927±0.00 5.322±0.00 N/A 3.999±0.00 N/A N/A
ENST00000588969 N/A N/A 4.757±0.00 N/A 8.529±0.00 7.563±0.00 2.530±0.00 5.743±0.00 5.085±0.00 11.331±0.00 6.816±0.00 8.358±0.00 5.471±0.00 N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0006IK CIL_0006IK_0001 CGP 17:42287547-42388568
CIL_00046I CIL_00046I_0001 CGP 17:42313324-42423517

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 TAS negative regulation of transcription from RNA polymerase II promoter
GO:0000981 IEA sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001103 IPI RNA polymerase II repressing transcription factor binding
GO:0001659 ISS temperature homeostasis
GO:0001754 ISS eye photoreceptor cell differentiation
GO:0003677 ISS DNA binding
GO:0003700 TAS:IEA sequence-specific DNA binding transcription factor activity
GO:0004871 IEA signal transducer activity
GO:0004879 IDA ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0005509 IEA calcium ion binding
GO:0005515 IPI protein binding
GO:0005634 IDA:ISS:IEA nucleus
GO:0005654 TAS nucleoplasm
GO:0005737 IDA:ISS cytoplasm
GO:0005743 IEA mitochondrial inner membrane
GO:0005829 TAS cytosol
GO:0005886 ISS plasma membrane
GO:0006355 IDA:IEA regulation of transcription, DNA-templated
GO:0006357 ISS regulation of transcription from RNA polymerase II promoter
GO:0006366 IEA transcription from RNA polymerase II promoter
GO:0006606 IDA protein import into nucleus
GO:0006928 TAS cellular component movement
GO:0006953 IEA acute-phase response
GO:0007165 TAS:IEA signal transduction
GO:0007259 TAS JAK-STAT cascade
GO:0007399 TAS nervous system development
GO:0008134 IPI transcription factor binding
GO:0008283 IEA cell proliferation
GO:0008285 IEA negative regulation of cell proliferation
GO:0010033 IEA response to organic substance
GO:0014070 IEA response to organic cyclic compound
GO:0016032 IEA viral process
GO:0016310 ISS phosphorylation
GO:0019221 NAS cytokine-mediated signaling pathway
GO:0019827 IEA stem cell maintenance
GO:0019901 ISS protein kinase binding
GO:0019903 IPI protein phosphatase binding
GO:0019953 ISS sexual reproduction
GO:0030522 IDA intracellular receptor signaling pathway
GO:0031730 IEA CCR5 chemokine receptor binding
GO:0032355 IDA response to estradiol
GO:0032870 IDA cellular response to hormone stimulus
GO:0034097 IEA response to cytokine
GO:0035259 IEA glucocorticoid receptor binding
GO:0040014 IEA regulation of multicellular organism growth
GO:0042493 IEA response to drug
GO:0042593 ISS glucose homeostasis
GO:0042755 ISS eating behavior
GO:0043434 IEA response to peptide hormone
GO:0043565 IEA sequence-specific DNA binding
GO:0044212 IDA transcription regulatory region DNA binding
GO:0045471 IEA response to ethanol
GO:0045747 ISS positive regulation of Notch signaling pathway
GO:0045820 IEA negative regulation of glycolytic process
GO:0045893 ISS positive regulation of transcription, DNA-templated
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0046983 ISS protein dimerization activity
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0048708 ISS astrocyte differentiation
GO:0060019 ISS radial glial cell differentiation
GO:0060396 IDA growth hormone receptor signaling pathway
GO:0060397 ISS JAK-STAT cascade involved in growth hormone signaling pathway
GO:0060548 IEA negative regulation of cell death
GO:0070102 IDA interleukin-6-mediated signaling pathway
GO:2001223 IEA negative regulation of neuron migration

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000022712 stat3 signal transduction and activation of transcription 3 protein_coding Danio_rerio
ENSMUSG00000004040 Stat3 signal transducer and activator of transcription 3 protein_coding Mus_musculus

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