C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: cullin 3
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000004364 Cul3 10090 - 1:80264923-80340480 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000163119 Cul3-001 80264923-80340480 protein_coding
  ENSMUST00000164108 Cul3-002 80266823-80340311 protein_coding
  ENSMUST00000167293 Cul3-004 80288831-80340279 nonsense_mediated_decay
  ENSMUST00000167794 Cul3-006 80267242-80276566 retained_intron
  ENSMUST00000168372 Cul3-005 80266947-80277441 protein_coding
  ENSMUST00000170897 Cul3-003 80287050-80340307 nonsense_mediated_decay

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000163119ENSMUST00000164108
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000163119 4.411±0.86 4.250±1.39 5.851±1.81 8.913±1.29 3.268±0.77 2.546±0.97 5.413±0.92 2.712±0.59 3.506±1.61 4.285±0.13 14.826±6.28 4.119±1.74 5.340±0.60 6.455±0.86
ENSMUST00000164108 7.711±0.71 6.504±2.07 17.983±0.23 20.666±15.85 9.953±2.61 4.578±1.83 11.293±0.78 11.605±1.22 9.745±2.16 7.863±1.58 39.504±3.43 14.499±13.72 33.436±19.91 88.542±60.90

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0006XN CIL_0006XN_0002 CGP 1:80198706-80340480
CIL_0006XM CIL_0006XM_0002 CGP 1:80264923-80758527

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000139 IEA Golgi membrane
GO:0000209 ISS protein polyubiquitination
GO:0000902 IMP cell morphogenesis
GO:0001701 IMP in utero embryonic development
GO:0001831 IMP trophectodermal cellular morphogenesis
GO:0004842 ISS ubiquitin-protein transferase activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005794 IDA Golgi apparatus
GO:0005827 ISS polar microtubule
GO:0006513 ISS protein monoubiquitination
GO:0006888 ISS ER to Golgi vesicle-mediated transport
GO:0007080 ISS mitotic metaphase plate congression
GO:0007229 IMP integrin-mediated signaling pathway
GO:0007369 IMP gastrulation
GO:0008054 ISS cyclin catabolic process
GO:0016020 IEA membrane
GO:0016055 IDA Wnt signaling pathway
GO:0016477 ISS cell migration
GO:0016567 ISS protein ubiquitination
GO:0017145 IMP stem cell division
GO:0030332 IPI cyclin binding
GO:0031208 ISS POZ domain binding
GO:0031461 IEA cullin-RING ubiquitin ligase complex
GO:0031463 ISS Cul3-RING ubiquitin ligase complex
GO:0031625 IEA ubiquitin protein ligase binding
GO:0032467 ISS positive regulation of cytokinesis
GO:0035024 ISS negative regulation of Rho protein signal transduction
GO:0040016 IMP embryonic cleavage
GO:0042803 IDA protein homodimerization activity
GO:0043149 ISS stress fiber assembly
GO:0043161 ISS proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045842 ISS positive regulation of mitotic metaphase/anaphase transition
GO:0046982 IPI protein heterodimerization activity
GO:0048208 ISS COPII vesicle coating
GO:0070062 IEA extracellular vesicular exosome

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000038967 cul3a cullin 3a protein_coding Danio_rerio
ENSDARG00000090602 cullin 3 protein_coding Danio_rerio
ENSG00000036257 CUL3 cullin 3 protein_coding Homo_sapiens

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