C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: cullin 3
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000036257 CUL3 9606 - 2:224470150-224585397 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000264414 CUL3-001 224470150-224585348 protein_coding
  ENST00000344951 CUL3-201 224470150-224585397 protein_coding
  ENST00000409096 CUL3-002 224473922-224569825 protein_coding
  ENST00000409777 CUL3-003 224473939-224563299 protein_coding
  ENST00000432260 CUL3-013 224513615-224557820 nonsense_mediated_decay
  ENST00000436172 CUL3-006 224514636-224563320 protein_coding
  ENST00000451538 CUL3-011 224474033-224497819 protein_coding
  ENST00000454323 CUL3-010 224473910-224495906 nonsense_mediated_decay
  ENST00000481135 CUL3-009 224502992-224504324 retained_intron
  ENST00000484081 CUL3-008 224505749-224511411 retained_intron
  ENST00000487558 CUL3-004 224495006-224500397 retained_intron
  ENST00000497715 CUL3-005 224473902-224480124 retained_intron
  ENST00000536702 CUL3-015 224478303-224485384 processed_transcript
  ENST00000541548 CUL3-014 224511438-224533094 processed_transcript
  ENST00000546102 CUL3-012 224535607-224560668 processed_transcript
  ENST00000617432 CUL3-202 224473934-224505971 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000264414ENST00000409096ENST00000454323ENST00000617432
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000264414 1.159±0.00 1.510±0.00 0.819±0.00 2.762±0.55 1.036±0.16 1.005±0.06 0.826±0.31 1.424±0.00 0.840±0.00 0.968±0.10 2.353±0.00 1.739±0.45 0.980±0.09 N/A
ENST00000409096 12.673±0.00 N/A 2.445±0.00 8.343±3.16 8.841±2.93 2.163±0.00 8.229±4.97 9.683±5.68 5.971±1.03 6.911±2.23 24.106±0.00 14.325±10.24 5.114±2.19 203.452±0.00
ENST00000454323 N/A 13.890±0.00 N/A N/A N/A 8.141±0.00 N/A N/A N/A N/A N/A N/A N/A 50.969±0.00
ENST00000617432 5.653±0.00 10.295±0.00 8.572±0.00 10.825±2.93 6.749±0.39 6.429±0.17 5.600±1.39 11.289±2.55 8.757±0.70 9.128±1.04 15.248±6.24 12.002±0.84 7.118±0.20 43.450±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0006XN CIL_0006XN_0001 CGP 2:224378698-224585397
CIL_0006XM CIL_0006XM_0001 CGP 2:224470150-225042445

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000082 TAS G1/S transition of mitotic cell cycle
GO:0000139 IMP Golgi membrane
GO:0000209 IDA protein polyubiquitination
GO:0000902 IEA cell morphogenesis
GO:0001701 IEA in utero embryonic development
GO:0001831 IEA trophectodermal cellular morphogenesis
GO:0004842 IDA ubiquitin-protein transferase activity
GO:0005515 IPI protein binding
GO:0005634 IEA nucleus
GO:0005794 IEA Golgi apparatus
GO:0005827 IDA polar microtubule
GO:0006511 IEA ubiquitin-dependent protein catabolic process
GO:0006513 IDA protein monoubiquitination
GO:0006888 IDA ER to Golgi vesicle-mediated transport
GO:0007050 TAS cell cycle arrest
GO:0007080 IMP mitotic metaphase plate congression
GO:0007229 ISS integrin-mediated signaling pathway
GO:0007369 IEA gastrulation
GO:0008054 IDA cyclin catabolic process
GO:0008284 TAS positive regulation of cell proliferation
GO:0016020 IDA membrane
GO:0016055 IEA Wnt signaling pathway
GO:0016477 IMP cell migration
GO:0016567 IDA protein ubiquitination
GO:0017145 ISS stem cell division
GO:0030332 IEA cyclin binding
GO:0031208 IDA POZ domain binding
GO:0031461 IEA cullin-RING ubiquitin ligase complex
GO:0031463 IDA Cul3-RING ubiquitin ligase complex
GO:0031625 IEA ubiquitin protein ligase binding
GO:0032467 IMP positive regulation of cytokinesis
GO:0035024 IMP negative regulation of Rho protein signal transduction
GO:0040016 ISS embryonic cleavage
GO:0042803 IEA protein homodimerization activity
GO:0043149 IMP stress fiber assembly
GO:0043161 IDA proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045842 IMP positive regulation of mitotic metaphase/anaphase transition
GO:0046982 IEA protein heterodimerization activity
GO:0048208 IMP COPII vesicle coating
GO:0070062 IDA extracellular vesicular exosome
GO:0097193 TAS intrinsic apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000038967 cul3a cullin 3a protein_coding Danio_rerio
ENSDARG00000090602 cullin 3 protein_coding Danio_rerio
ENSMUSG00000004364 Cul3 cullin 3 protein_coding Mus_musculus

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