C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: adenomatosis polyposis coli
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000005871 Apc 10090 + 18:34220924-34322189 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000066133 Apc-005 34247698-34290345 protein_coding
  ENSMUST00000079362 Apc-001 34220984-34318608 protein_coding
  ENSMUST00000115781 Apc-201 34220984-34322189 protein_coding
  ENSMUST00000163295 Apc-008 34221252-34276591 nonsense_mediated_decay
  ENSMUST00000165590 Apc-006 34299966-34314326 nonsense_mediated_decay
  ENSMUST00000167136 Apc-007 34301261-34310737 processed_transcript
  ENSMUST00000170023 Apc-003 34221013-34300202 retained_intron
  ENSMUST00000170195 Apc-004 34247694-34263695 retained_intron
  ENSMUST00000171187 Apc-002 34220924-34313506 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000079362ENSMUST00000115781ENSMUST00000171187
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000079362 3.810±0.53 1.634±0.61 2.499±0.73 4.560±0.00 3.501±0.83 3.631±0.38 1.451±0.23 2.621±0.56 0.835±0.32 4.816±0.83 0.485±0.00 3.987±0.92 3.980±2.23 1.163±0.17
ENSMUST00000115781 N/A 2.261±0.33 N/A 20.821±5.54 2.243±0.09 2.144±0.39 0.317±0.00 0.640±0.16 0.693±0.47 3.084±0.00 N/A 1.166±0.30 2.637±0.05 N/A
ENSMUST00000171187 N/A N/A N/A N/A N/A 1.575±0.00 N/A N/A N/A N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0005KL CIL_0005KL_0003 CGP 18:33796327-34322189

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000281 IMP mitotic cytokinesis
GO:0000776 IEA kinetochore
GO:0001822 IMP kidney development
GO:0001942 IMP hair follicle development
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0005813 IEA centrosome
GO:0005881 IDA cytoplasmic microtubule
GO:0005886 IEA plasma membrane
GO:0005913 IEA cell-cell adherens junction
GO:0005923 IEA tight junction
GO:0006461 IEA protein complex assembly
GO:0006974 IEA cellular response to DNA damage stimulus
GO:0007026 IMP negative regulation of microtubule depolymerization
GO:0007050 IEA cell cycle arrest
GO:0007091 IGI metaphase/anaphase transition of mitotic cell cycle
GO:0007094 IEA mitotic spindle assembly checkpoint
GO:0007389 IMP pattern specification process
GO:0007409 IMP axonogenesis
GO:0008013 IDA beta-catenin binding
GO:0008285 IMP negative regulation of cell proliferation
GO:0009798 IMP axis specification
GO:0009952 IMP anterior/posterior pattern specification
GO:0009953 IMP dorsal/ventral pattern formation
GO:0009954 IMP proximal/distal pattern formation
GO:0016055 IDA Wnt signaling pathway
GO:0016328 IEA lateral plasma membrane
GO:0016477 IMP cell migration
GO:0019827 IMP stem cell maintenance
GO:0019887 IEA protein kinase regulator activity
GO:0019901 IEA protein kinase binding
GO:0030027 IEA lamellipodium
GO:0030178 IMP negative regulation of Wnt signaling pathway
GO:0030334 IGI regulation of cell migration
GO:0030335 IMP positive regulation of cell migration
GO:0030424 IDA axon
GO:0030426 IDA growth cone
GO:0030856 IMP regulation of epithelial cell differentiation
GO:0030858 IGI positive regulation of epithelial cell differentiation
GO:0030877 IEA beta-catenin destruction complex
GO:0031116 IMP positive regulation of microtubule polymerization
GO:0031122 IGI cytoplasmic microtubule organization
GO:0031253 IDA cell projection membrane
GO:0031274 IEA positive regulation of pseudopodium assembly
GO:0032587 IEA ruffle membrane
GO:0032886 IEA regulation of microtubule-based process
GO:0033077 IMP T cell differentiation in thymus
GO:0035019 IGI somatic stem cell maintenance
GO:0035371 IDA microtubule plus-end
GO:0042483 IMP negative regulation of odontogenesis
GO:0042995 IDA cell projection
GO:0043065 IMP positive regulation of apoptotic process
GO:0043066 IMP negative regulation of apoptotic process
GO:0043409 IGI negative regulation of MAPK cascade
GO:0043588 IMP skin development
GO:0044295 IDA axonal growth cone
GO:0044336 IGI canonical Wnt signaling pathway involved in negative regulation of apoptotic process
GO:0044337 IGI canonical Wnt signaling pathway involved in positive regulation of apoptotic process
GO:0045295 IEA gamma-catenin binding
GO:0045595 IGI regulation of cell differentiation
GO:0045597 IMP positive regulation of cell differentiation
GO:0045667 IMP regulation of osteoblast differentiation
GO:0045670 IMP regulation of osteoclast differentiation
GO:0045732 IMP positive regulation of protein catabolic process
GO:0045736 IEA negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0045785 IMP positive regulation of cell adhesion
GO:0046716 IGI muscle cell cellular homeostasis
GO:0048538 IMP thymus development
GO:0050680 IGI negative regulation of epithelial cell proliferation
GO:0051010 IDA microtubule plus-end binding
GO:0051171 IMP regulation of nitrogen compound metabolic process
GO:0051276 IGI chromosome organization
GO:0051726 IMP regulation of cell cycle
GO:0051781 IMP positive regulation of cell division
GO:0051988 IMP regulation of attachment of spindle microtubules to kinetochore
GO:0060041 IMP retina development in camera-type eye
GO:0060070 IMP canonical Wnt signaling pathway
GO:0060770 IMP negative regulation of epithelial cell proliferation involved in prostate gland development
GO:0090090 IMP negative regulation of canonical Wnt signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000058868 apc adenomatosis polyposis coli protein_coding Danio_rerio
ENSG00000134982 APC adenomatous polyposis coli protein_coding Homo_sapiens

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