C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: pyruvate dehydrogenase kinase, isoenzyme 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000006494 Pdk1 10090 + 2:71873224-71903858 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000006669 Pdk1-001 71873224-71903858 protein_coding
  ENSMUST00000129427 Pdk1-008 71887418-71896493 processed_transcript
  ENSMUST00000129887 Pdk1-005 71875079-71883607 processed_transcript
  ENSMUST00000134362 Pdk1-007 71873326-71886312 processed_transcript
  ENSMUST00000148249 Pdk1-006 71873551-71884184 processed_transcript
  ENSMUST00000151358 Pdk1-003 71873743-71888952 processed_transcript
  ENSMUST00000152696 Pdk1-004 71873320-71883932 processed_transcript
  ENSMUST00000156036 Pdk1-002 71873346-71901986 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000006669ENSMUST00000134362ENSMUST00000151358ENSMUST00000152696ENSMUST00000156036
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000006669 7.098±2.05 7.442±1.35 7.263±0.44 4.310±1.34 9.831±5.25 6.952±1.14 17.767±4.86 7.289±0.83 8.148±1.14 4.999±0.67 11.331±1.04 4.985±1.41 3.943±1.69 1.189±0.59
ENSMUST00000134362 N/A 20.774±3.12 N/A N/A 20.580±6.66 4.827±0.00 N/A N/A 11.486±0.50 5.013±1.15 N/A 5.829±1.22 N/A 1.565±0.00
ENSMUST00000151358 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 6.483±1.40 N/A
ENSMUST00000152696 N/A 95.006±21.48 N/A N/A N/A 13.333±1.27 N/A N/A N/A N/A N/A 9.808±3.07 N/A N/A
ENSMUST00000156036 3.725±0.40 N/A 4.307±0.59 1.104±0.00 4.139±0.83 N/A N/A 1.918±0.23 9.194±2.19 2.297±0.27 N/A 4.574±1.16 5.875±1.98 1.553±0.53

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0004K8 CIL_0004K8_0002 CGP 2:71745616-71903858
CIL_0004KA CIL_0004KA_0002 CGP 2:71873224-72257474

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004672 IEA protein kinase activity
GO:0004674 IEA protein serine/threonine kinase activity
GO:0004740 ISS pyruvate dehydrogenase (acetyl-transferring) kinase activity
GO:0005515 IEA protein binding
GO:0005524 IEA ATP binding
GO:0005739 IDA mitochondrion
GO:0005886 ISA plasma membrane
GO:0005967 IDA mitochondrial pyruvate dehydrogenase complex
GO:0006006 IEA glucose metabolic process
GO:0006468 IEA protein phosphorylation
GO:0008283 ISS cell proliferation
GO:0008631 ISS intrinsic apoptotic signaling pathway in response to oxidative stress
GO:0010510 IMP regulation of acetyl-CoA biosynthetic process from pyruvate
GO:0010906 ISS regulation of glucose metabolic process
GO:0035556 ISA intracellular signal transduction
GO:0097411 ISS hypoxia-inducible factor-1alpha signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000013128 pdk1 pyruvate dehydrogenase kinase, isozyme 1 protein_coding Danio_rerio
ENSG00000152256 PDK1 pyruvate dehydrogenase kinase, isozyme 1 protein_coding Homo_sapiens

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