C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: pyruvate dehydrogenase kinase, isozyme 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000152256 PDK1 9606 + 2:172555373-172608669 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000282077 PDK1-001 172555969-172608669 protein_coding
  ENST00000392571 PDK1-003 172556007-172595969 protein_coding
  ENST00000410055 PDK1-002 172556051-172599137 protein_coding
  ENST00000416991 PDK1-008 172556313-172570812 protein_coding
  ENST00000431718 PDK1-006 172556102-172570820 nonsense_mediated_decay
  ENST00000436490 PDK1-005 172555627-172564687 nonsense_mediated_decay
  ENST00000439519 PDK1-007 172556565-172565073 protein_coding
  ENST00000443353 PDK1-004 172555373-172565073 protein_coding
  ENST00000466437 PDK1-009 172570585-172595962 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdrenalBrainBreastHeartLiverLungMuscleOvaryENST00000282077ENST00000410055
Transcript ID Adrenal Brain Breast Heart Liver Lung Muscle Ovary
ENST00000282077 1.448±0.00 0.660±0.02 1.766±0.00 1.714±0.00 0.672±0.44 1.975±0.00 N/A 2.122±1.58
ENST00000410055 N/A 3.182±0.00 N/A 6.729±0.00 1.344±0.00 N/A 1.796±0.00 3.261±1.46

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0004K8 CIL_0004K8_0001 CGP 2:172427354-172608669
CIL_0004KA CIL_0004KA_0001 CGP 2:172555373-173052893

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004672 IDA protein kinase activity
GO:0004674 IEA protein serine/threonine kinase activity
GO:0004740 IMP pyruvate dehydrogenase (acetyl-transferring) kinase activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005739 TAS mitochondrion
GO:0005759 TAS mitochondrial matrix
GO:0005967 IEA mitochondrial pyruvate dehydrogenase complex
GO:0006006 IEA glucose metabolic process
GO:0006090 TAS pyruvate metabolic process
GO:0006468 IEA protein phosphorylation
GO:0008283 IMP cell proliferation
GO:0008631 IMP intrinsic apoptotic signaling pathway in response to oxidative stress
GO:0010510 TAS regulation of acetyl-CoA biosynthetic process from pyruvate
GO:0010906 IMP regulation of glucose metabolic process
GO:0044237 TAS cellular metabolic process
GO:0044281 TAS small molecule metabolic process
GO:0097411 IMP hypoxia-inducible factor-1alpha signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000013128 pdk1 pyruvate dehydrogenase kinase, isozyme 1 protein_coding Danio_rerio
ENSMUSG00000006494 Pdk1 pyruvate dehydrogenase kinase, isoenzyme 1 protein_coding Mus_musculus

Loading