C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: pyruvate dehydrogenase kinase, isoenzyme 1
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000006669 Pdk1-001 ENSMUSG00000006494 10090 + 2:71873224-71903858 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000006669
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000006669 7.098±2.05 7.442±1.35 7.263±0.44 4.310±1.34 9.831±5.25 6.952±1.14 17.767±4.86 7.289±0.83 8.148±1.14 4.999±0.67 11.331±1.04 4.985±1.41 3.943±1.69 1.189±0.59

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0004K8 CIL_0004K8_0002 CGP 2:71745616-71903858
CIL_0004KA CIL_0004KA_0002 CGP 2:71873224-72257474

Gene Ontology

GO IDEvidence TypeGO Description
GO:0004672 IEA protein kinase activity
GO:0004674 IEA protein serine/threonine kinase activity
GO:0004740 ISS pyruvate dehydrogenase (acetyl-transferring) kinase activity
GO:0005515 IEA protein binding
GO:0005524 IEA ATP binding
GO:0005739 IDA mitochondrion
GO:0005886 ISA plasma membrane
GO:0005967 IDA mitochondrial pyruvate dehydrogenase complex
GO:0006006 IEA glucose metabolic process
GO:0006468 IEA protein phosphorylation
GO:0008283 ISS cell proliferation
GO:0008631 ISS intrinsic apoptotic signaling pathway in response to oxidative stress
GO:0010510 IMP regulation of acetyl-CoA biosynthetic process from pyruvate
GO:0010906 ISS regulation of glucose metabolic process
GO:0035556 ISA intracellular signal transduction
GO:0097411 ISS hypoxia-inducible factor-1alpha signaling pathway

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENST00000282077 PDK1-001 protein_coding Homo_sapiens 0 1502
ENST00000392571 PDK1-003 protein_coding Homo_sapiens 0 1062
ENST00000410055 PDK1-002 protein_coding Homo_sapiens 0 1491
ENST00000416991 PDK1-008 protein_coding Homo_sapiens 0 660
ENST00000431718 PDK1-006 nonsense_mediated_decay Homo_sapiens 0 416
ENST00000436490 PDK1-005 nonsense_mediated_decay Homo_sapiens 0 274
ENST00000439519 PDK1-007 protein_coding Homo_sapiens 0 623
ENST00000443353 PDK1-004 protein_coding Homo_sapiens 0 623

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