C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: breast cancer 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000017146 Brca1 10090 - 11:101488764-101551955 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000017290 Brca1-001 101488764-101551879 protein_coding
  ENSMUST00000131460 Brca1-004 101512511-101522459 retained_intron
  ENSMUST00000142086 Brca1-002 101525507-101551955 nonsense_mediated_decay
  ENSMUST00000156843 Brca1-003 101496315-101508178 retained_intron
  ENSMUST00000188168 Brca1-006 101524207-101525206 processed_transcript
  ENSMUST00000190862 Brca1-005 101532083-101551582 protein_coding
  ENSMUST00000191198 Brca1-007 101524193-101524858 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000017290ENSMUST00000131460ENSMUST00000142086ENSMUST00000156843ENSMUST00000188168ENSMUST00000191198
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000017290 0.242±0.00 0.123±0.05 0.199±0.01 1.063±0.19 0.132±0.07 N/A 0.021±0.01 0.054±0.02 3.120±2.75 0.117±0.02 0.027±0.02 1.634±0.99 4.167±2.73 2.236±0.61
ENSMUST00000131460 N/A 0.135±0.00 N/A N/A N/A N/A N/A 0.205±0.00 N/A N/A N/A N/A N/A N/A
ENSMUST00000142086 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.029±0.01 N/A N/A N/A
ENSMUST00000156843 N/A 0.051±0.00 N/A N/A N/A 0.497±0.00 N/A 0.052±0.00 0.048±0.00 N/A 0.024±0.00 N/A N/A N/A
ENSMUST00000188168 N/A 0.343±0.00 N/A N/A 0.254±0.05 N/A 0.095±0.01 N/A 0.107±0.00 N/A 0.047±0.00 1.902±0.34 N/A N/A
ENSMUST00000191198 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.041±0.00 N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00061F CIL_00061F_0002 CGP 11:101464999-101551955
CIL_00040M CIL_00040M_0002 CGP 11:101488764-101581951

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000724 IEA double-strand break repair via homologous recombination
GO:0000793 IDA condensed chromosome
GO:0000794 IDA condensed nuclear chromosome
GO:0003684 IDA damaged DNA binding
GO:0003723 ISO RNA binding
GO:0004842 ISS ubiquitin-protein transferase activity
GO:0005654 TAS nucleoplasm
GO:0005694 IDA chromosome
GO:0005737 IDA cytoplasm
GO:0005813 TAS centrosome
GO:0005886 IEA plasma membrane
GO:0006260 IMP DNA replication
GO:0006281 IEA DNA repair
GO:0006301 IEA postreplication repair
GO:0006302 IEA double-strand break repair
GO:0006310 IEA DNA recombination
GO:0006349 IMP regulation of gene expression by genetic imprinting
GO:0006633 IEA fatty acid biosynthetic process
GO:0006974 IMP cellular response to DNA damage stimulus
GO:0007059 IEA chromosome segregation
GO:0007098 IGI centrosome cycle
GO:0008270 IEA zinc ion binding
GO:0008630 ISO intrinsic apoptotic signaling pathway in response to DNA damage
GO:0009048 IDA dosage compensation by inactivation of X chromosome
GO:0010212 IEA response to ionizing radiation
GO:0010575 IEA positive regulation vascular endothelial growth factor production
GO:0010628 IEA positive regulation of gene expression
GO:0016874 IEA ligase activity
GO:0019899 IEA enzyme binding
GO:0030529 ISO ribonucleoprotein complex
GO:0031398 IEA positive regulation of protein ubiquitination
GO:0031436 ISS BRCA1-BARD1 complex
GO:0031572 IEA G2 DNA damage checkpoint
GO:0031625 IEA ubiquitin protein ligase binding
GO:0035066 IMP positive regulation of histone acetylation
GO:0035067 IMP negative regulation of histone acetylation
GO:0043009 IMP chordate embryonic development
GO:0043234 IEA protein complex
GO:0043627 IEA response to estrogen
GO:0044030 IMP regulation of DNA methylation
GO:0044212 IDA transcription regulatory region DNA binding
GO:0045717 ISS negative regulation of fatty acid biosynthetic process
GO:0045739 IEA positive regulation of DNA repair
GO:0045766 IEA positive regulation of angiogenesis
GO:0045892 IEA negative regulation of transcription, DNA-templated
GO:0045944 IMP positive regulation of transcription from RNA polymerase II promoter
GO:0051298 TAS centrosome duplication
GO:0051571 IMP positive regulation of histone H3-K4 methylation
GO:0051572 IMP negative regulation of histone H3-K4 methylation
GO:0051573 IMP negative regulation of histone H3-K9 methylation
GO:0051574 IMP positive regulation of histone H3-K9 methylation
GO:0051865 ISS protein autoubiquitination
GO:0070512 IMP positive regulation of histone H4-K20 methylation
GO:0070531 IEA BRCA1-A complex
GO:0071158 IEA positive regulation of cell cycle arrest
GO:0071356 IEA cellular response to tumor necrosis factor
GO:0071681 IEA cellular response to indole-3-methanol
GO:0085020 ISS protein K6-linked ubiquitination
GO:1902042 IEA negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:2000378 IEA negative regulation of reactive oxygen species metabolic process
GO:2000617 IMP positive regulation of histone H3-K9 acetylation
GO:2000620 IMP positive regulation of histone H4-K16 acetylation

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSG00000012048 BRCA1 breast cancer 1, early onset protein_coding Homo_sapiens

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