C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: tissue inhibitor of metalloproteinase 3
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000020044 Timp3 10090 + 10:86300372-86349506 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000020234 Timp3-001 86300372-86349506 protein_coding
  ENSMUST00000132307 Timp3-004 86302854-86343981 protein_coding
  ENSMUST00000136045 Timp3-003 86300556-86326834 processed_transcript
  ENSMUST00000151134 Timp3-002 86300554-86306781 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000020234ENSMUST00000136045
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000020234 64.773±11.62 83.543±8.62 88.639±0.50 7.705±1.77 45.590±5.97 22.088±3.21 36.675±4.28 279.835±42.06 3.497±0.48 131.907±16.75 23.821±3.36 56.259±18.53 16.109±16.67 5.582±1.81
ENSMUST00000136045 N/A 156.835±11.88 N/A N/A 48.755±5.29 15.149±1.16 N/A N/A N/A 87.533±0.00 N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007RH CIL_0007RH_0002 VISTA 10:85994227-86597417
CIL_0002NM CIL_0002NM_0002 CGP 10:86021972-86498896
CIL_000337 CIL_000337_0002 CGP 10:86055125-86498896

Gene Ontology
GO IDEvidence TypeGO Description
GO:0005604 IDA basement membrane
GO:0005634 IEA nucleus
GO:0008191 IEA metalloendopeptidase inhibitor activity
GO:0010951 IEA negative regulation of endopeptidase activity
GO:0031012 IEA extracellular matrix
GO:0046872 IEA metal ion binding
GO:0051045 IEA negative regulation of membrane protein ectodomain proteolysis
GO:0070062 IEA extracellular vesicular exosome
GO:0071310 IDA cellular response to organic substance

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSG00000100234 TIMP3 TIMP metallopeptidase inhibitor 3 protein_coding Homo_sapiens

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