C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: dedicator of cyto-kinesis 2
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000101365 Dock2-002 ENSMUSG00000020143 10090 - 11:34273045-34783892 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdrenalHeartLiverLungPlacentaENSMUST00000101365
Transcript ID Adrenal Heart Liver Lung Placenta
ENSMUST00000101365 0.329±0.00 0.487±0.00 0.178±0.00 1.717±0.00 0.053±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0000OV CIL_0000OV_0003 CGP 11:34226815-34783892

Gene Ontology

GO IDEvidence TypeGO Description
GO:0001766 IMP membrane raft polarization
GO:0001768 IMP establishment of T cell polarity
GO:0001771 IMP immunological synapse formation
GO:0005085 IEA guanyl-nucleotide exchange factor activity
GO:0006935 IMP chemotaxis
GO:0007010 IDA cytoskeleton organization
GO:0007264 IEA small GTPase mediated signal transduction
GO:0030675 IMP Rac GTPase activator activity
GO:0032855 IMP positive regulation of Rac GTPase activity
GO:0035022 IC positive regulation of Rac protein signal transduction
GO:0042098 IMP T cell proliferation
GO:0042110 IMP T cell activation
GO:0045059 IMP positive thymic T cell selection
GO:0045060 IMP negative thymic T cell selection
GO:0046631 IMP alpha-beta T cell activation
GO:0046633 IMP alpha-beta T cell proliferation

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENST00000256935 DOCK2-001 protein_coding Homo_sapiens 0 4446
ENST00000280333 DOCK1-001 protein_coding Homo_sapiens 3e-31 143
ENST00000433448 DOCK2-011 nonsense_mediated_decay Homo_sapiens 0 337
ENST00000519223 DOCK2-013 retained_intron Homo_sapiens 0 608
ENST00000519628 DOCK2-015 protein_coding Homo_sapiens 0 479
ENST00000520181 DOCK2-017 processed_transcript Homo_sapiens 0 614
ENST00000520836 DOCK2-014 processed_transcript Homo_sapiens 0 734
ENST00000520908 DOCK2-004 protein_coding Homo_sapiens 0 2429
ENST00000522138 DOCK2-007 processed_transcript Homo_sapiens 0 640
ENST00000522994 DOCK2-010 processed_transcript Homo_sapiens 0 320
ENST00000523351 DOCK2-016 processed_transcript Homo_sapiens 0 1375
ENST00000523684 DOCK2-008 processed_transcript Homo_sapiens 0 671
ENST00000524185 DOCK2-002 nonsense_mediated_decay Homo_sapiens 0 3877
ENST00000540750 DOCK2-201 protein_coding Homo_sapiens 0 606
ENST00000623213 DOCK1-006 protein_coding Homo_sapiens 2e-31 143

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