C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: dedicator of cyto-kinesis 2
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000093193 Dock2-001 ENSMUSG00000020143 10090 - 11:34226815-34783892 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000093193
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000093193 2.279±0.71 0.557±0.19 1.134±0.03 0.172±0.08 10.892±3.48 0.890±0.24 0.512±0.22 0.987±0.45 1.433±0.95 3.603±1.63 0.251±0.36 1.031±0.43 0.292±0.14 0.656±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0000OV CIL_0000OV_0003 CGP 11:34226815-34783892

Gene Ontology

GO IDEvidence TypeGO Description
GO:0001766 IMP membrane raft polarization
GO:0001768 IMP establishment of T cell polarity
GO:0001771 IMP immunological synapse formation
GO:0002277 IMP myeloid dendritic cell activation involved in immune response
GO:0005737 IEA cytoplasm
GO:0005856 IEA cytoskeleton
GO:0006935 IMP chemotaxis
GO:0007010 IDA cytoskeleton organization
GO:0007264 IEA small GTPase mediated signal transduction
GO:0016020 IEA membrane
GO:0030675 IMP Rac GTPase activator activity
GO:0030676 ISS Rac guanyl-nucleotide exchange factor activity
GO:0032855 ISS positive regulation of Rac GTPase activity
GO:0035022 IC positive regulation of Rac protein signal transduction
GO:0042098 IMP T cell proliferation
GO:0042110 IMP T cell activation
GO:0042608 ISS T cell receptor binding
GO:0044351 IMP macropinocytosis
GO:0045059 IMP positive thymic T cell selection
GO:0045060 IMP negative thymic T cell selection
GO:0046631 IMP alpha-beta T cell activation
GO:0046633 IMP alpha-beta T cell proliferation
GO:0050766 IMP positive regulation of phagocytosis
GO:0070062 IEA extracellular vesicular exosome

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENST00000256935 DOCK2-001 protein_coding Homo_sapiens 0 7003
ENST00000280333 DOCK1-001 protein_coding Homo_sapiens 3e-31 143
ENST00000433448 DOCK2-011 nonsense_mediated_decay Homo_sapiens 0 462
ENST00000519223 DOCK2-013 retained_intron Homo_sapiens 0 608
ENST00000519628 DOCK2-015 protein_coding Homo_sapiens 0 479
ENST00000519868 DOCK2-006 retained_intron Homo_sapiens 0 231
ENST00000520181 DOCK2-017 processed_transcript Homo_sapiens 0 614
ENST00000520450 DOCK2-005 retained_intron Homo_sapiens 0 1341
ENST00000520836 DOCK2-014 processed_transcript Homo_sapiens 0 734
ENST00000520908 DOCK2-004 protein_coding Homo_sapiens 0 4985
ENST00000522138 DOCK2-007 processed_transcript Homo_sapiens 0 640
ENST00000522994 DOCK2-010 processed_transcript Homo_sapiens 0 320
ENST00000523351 DOCK2-016 processed_transcript Homo_sapiens 0 3932
ENST00000523684 DOCK2-008 processed_transcript Homo_sapiens 0 671
ENST00000524185 DOCK2-002 nonsense_mediated_decay Homo_sapiens 0 3877
ENST00000540750 DOCK2-201 protein_coding Homo_sapiens 0 606
ENST00000623213 DOCK1-006 protein_coding Homo_sapiens 2e-31 143

Loading