C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: hyperpolarization-activated, cyclic nucleotide-gated K+ 2
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000099513 Hcn2-001 ENSMUSG00000020331 10090 + 10:79716634-79736108 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000099513
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000099513 0.654±0.18 4.117±1.43 0.493±0.10 8.423±6.02 0.361±0.12 6.547±0.75 6.678±2.63 0.531±0.16 0.136±0.06 0.900±0.26 0.504±0.16 2.541±0.93 4.204±2.73 0.236±0.06

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008XG CIL_0008XG_0002 VISTA 10:79539861-80142369
CIL_00008I CIL_00008I_0002 CGP 10:79704491-79736108
CIL_0005ZK CIL_0005ZK_0003 CGP 10:79716634-79746581

Gene Ontology

GO IDEvidence TypeGO Description
GO:0005222 ISS intracellular cAMP activated cation channel activity
GO:0005248 IEA voltage-gated sodium channel activity
GO:0005249 ISS voltage-gated potassium channel activity
GO:0005515 IPI protein binding
GO:0005886 IEA plasma membrane
GO:0005887 ISS integral component of plasma membrane
GO:0030552 IEA cAMP binding
GO:0034765 IEA regulation of ion transmembrane transport
GO:0035725 IEA sodium ion transmembrane transport
GO:0042391 IDA regulation of membrane potential
GO:0042802 IEA identical protein binding
GO:0071320 ISS cellular response to cAMP
GO:0071321 IEA cellular response to cGMP
GO:0071805 ISS potassium ion transmembrane transport

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSDART00000093300 hcn4-201 protein_coding Danio_rerio 0 1277
ENSDART00000136140 hcn4-001 protein_coding Danio_rerio 0 1277
ENST00000251287 HCN2-001 protein_coding Homo_sapiens 0 2874
ENST00000261917 HCN4-001 protein_coding Homo_sapiens 0 1591
ENST00000303230 HCN1-001 protein_coding Homo_sapiens 0.000008 58
ENST00000368358 HCN3-001 protein_coding Homo_sapiens 0 1090
ENST00000467204 HCN3-003 processed_transcript Homo_sapiens 0 318
ENST00000496230 HCN3-002 processed_transcript Homo_sapiens 0 505
ENST00000568218 RP13-395E19.2-001 processed_pseudogene Homo_sapiens 0 2433
ENST00000569415 RP11-261B23.1-001 processed_pseudogene Homo_sapiens 0 2425
ENST00000572822 HCN3-002 processed_transcript Homo_sapiens 0 505
ENST00000575670 HCN3-001 protein_coding Homo_sapiens 0 1090
ENST00000576844 HCN3-003 processed_transcript Homo_sapiens 0 318
ENST00000589661 AC005559.3-001 processed_pseudogene Homo_sapiens 0 228

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