C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: estrogen receptor 2 (beta)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000021055 Esr2 10090 - 12:76120419-76177259 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000076634 Esr2-201 76120439-76177259 protein_coding
  ENSMUST00000101291 Esr2-002 76120419-76177259 protein_coding
  ENSMUST00000110421 Esr2-001 76120419-76167715 protein_coding
  ENSMUST00000133564 Esr2-003 76120419-76177259 nonsense_mediated_decay

Mus musculus EnsemblGRCm38

Genome
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Genes
Gene structures from Ensembl
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Transcripts
Structures from Ensembl
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Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000076634ENSMUST00000101291ENSMUST00000110421ENSMUST00000133564
Transcript ID Adipose Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000076634 N/A 0.152±0.00 0.022±0.00 N/A 0.332±0.16 N/A N/A N/A N/A N/A 11.794±4.82 0.019±0.00 0.168±0.01
ENSMUST00000101291 0.017±0.00 0.030±0.00 N/A N/A 0.203±0.00 N/A N/A N/A 0.841±0.38 N/A 10.517±3.56 0.014±0.00 N/A
ENSMUST00000110421 0.056±0.03 0.054±0.00 0.020±0.00 0.034±0.02 0.248±0.09 0.031±0.01 0.103±0.05 0.015±0.01 0.403±0.09 0.057±0.01 11.634±4.99 0.029±0.03 0.055±0.04
ENSMUST00000133564 N/A N/A 0.083±0.00 0.029±0.00 0.251±0.08 0.081±0.00 N/A 0.011±0.00 N/A N/A 7.545±4.74 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00010O CIL_00010O_0002 CGP 12:75818134-76177259

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IEA negative regulation of transcription from RNA polymerase II promoter
GO:0001046 IEA core promoter sequence-specific DNA binding
GO:0001541 IMP ovarian follicle development
GO:0001764 IMP neuron migration
GO:0003677 IDA DNA binding
GO:0003700 IEA sequence-specific DNA binding transcription factor activity
GO:0003707 IEA steroid hormone receptor activity
GO:0004879 IEA ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0005496 ISS steroid binding
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0005739 IEA mitochondrion
GO:0006351 IEA transcription, DNA-templated
GO:0006355 IEA regulation of transcription, DNA-templated
GO:0007420 IMP brain development
GO:0008270 IEA zinc ion binding
GO:0008285 IGI negative regulation of cell proliferation
GO:0008628 IMP hormone-mediated apoptotic signaling pathway
GO:0019899 IEA enzyme binding
GO:0030284 IEA estrogen receptor activity
GO:0030520 IMP intracellular estrogen receptor signaling pathway
GO:0034056 IEA estrogen response element binding
GO:0042127 IMP regulation of cell proliferation
GO:0043401 IEA steroid hormone mediated signaling pathway
GO:0043565 IEA sequence-specific DNA binding
GO:0050680 IMP negative regulation of epithelial cell proliferation
GO:0051091 ISS positive regulation of sequence-specific DNA binding transcription factor activity
GO:0060065 IGI uterus development
GO:0060068 IGI vagina development
GO:0060740 IMP prostate gland epithelium morphogenesis
GO:0060743 IMP epithelial cell maturation involved in prostate gland development
GO:0060766 IMP negative regulation of androgen receptor signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000016454 esr2a estrogen receptor 2a protein_coding Danio_rerio
ENSDARG00000034181 esr2b estrogen receptor 2b protein_coding Danio_rerio
ENSG00000140009 ESR2 estrogen receptor 2 (ER beta) protein_coding Homo_sapiens

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