C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: estrogen receptor 2 (ER beta)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000140009 ESR2 9606 - 14:64084232-64338112 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000267525 ESR2-201 64233029-64283075 protein_coding
  ENST00000341099 ESR2-001 64233088-64294360 protein_coding
  ENST00000344288 ESR2-008 64227506-64283036 nonsense_mediated_decay
  ENST00000353772 ESR2-202 64227035-64294410 protein_coding
  ENST00000358599 ESR2-002 64227427-64338112 protein_coding
  ENST00000553796 ESR2-011 64227818-64282985 protein_coding
  ENST00000554520 ESR2-006 64233070-64282813 processed_transcript
  ENST00000554572 ESR2-003 64226707-64338096 protein_coding
  ENST00000555278 ESR2-012 64227453-64282985 protein_coding
  ENST00000555483 ESR2-007 64233029-64282842 processed_transcript
  ENST00000555783 ESR2-009 64235063-64260527 processed_transcript
  ENST00000556275 ESR2-004 64084232-64294410 protein_coding
  ENST00000557772 ESR2-005 64230918-64282985 protein_coding

Homo sapiens EnsemblGRCh38

Genome
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Genes
Gene structures from Ensembl
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Transcripts
Structures from Ensembl
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Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000341099ENST00000344288ENST00000353772ENST00000358599ENST00000553796ENST00000554520ENST00000554572ENST00000555278ENST00000556275ENST00000557772
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000341099 N/A N/A N/A N/A 0.787±0.00 N/A N/A N/A N/A N/A N/A 3.662±0.00 N/A N/A
ENST00000344288 N/A N/A N/A N/A N/A N/A 0.176±0.00 0.540±0.00 N/A N/A N/A N/A N/A N/A
ENST00000353772 N/A N/A 0.148±0.00 N/A 0.599±0.00 N/A N/A N/A N/A N/A 0.230±0.00 N/A N/A N/A
ENST00000358599 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.078±0.00 0.929±0.00
ENST00000553796 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.032±0.00 N/A
ENST00000554520 N/A N/A N/A N/A N/A 0.353±0.00 N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000554572 N/A N/A N/A 0.064±0.00 N/A N/A N/A 0.234±0.00 N/A N/A N/A 0.371±0.00 N/A 1.464±0.71
ENST00000555278 N/A N/A N/A N/A N/A N/A N/A 0.453±0.00 0.358±0.00 0.140±0.00 0.183±0.00 N/A 0.025±0.00 N/A
ENST00000556275 N/A 0.137±0.00 0.306±0.00 N/A 0.449±0.00 N/A N/A 0.288±0.00 0.250±0.00 0.103±0.00 0.152±0.00 N/A N/A N/A
ENST00000557772 0.057±0.00 0.132±0.00 0.266±0.00 N/A 0.560±0.00 0.060±0.00 0.075±0.01 0.254±0.20 0.037±0.00 0.086±0.00 0.127±0.01 0.588±0.00 0.032±0.02 1.071±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0004WO CIL_0004WO_0001 CGP 14:63684214-64226433
CIL_00010O CIL_00010O_0001 CGP 14:63852983-64338112

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IDA negative regulation of transcription from RNA polymerase II promoter
GO:0001046 IDA core promoter sequence-specific DNA binding
GO:0001541 IEA ovarian follicle development
GO:0001764 IEA neuron migration
GO:0003677 TAS DNA binding
GO:0003700 TAS:IEA sequence-specific DNA binding transcription factor activity
GO:0003707 TAS:IEA steroid hormone receptor activity
GO:0003713 TAS transcription coactivator activity
GO:0004879 IDA ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0005496 ISS steroid binding
GO:0005515 IPI protein binding
GO:0005576 NAS extracellular region
GO:0005634 TAS:IEA nucleus
GO:0005654 TAS nucleoplasm
GO:0005737 IEA cytoplasm
GO:0005739 IDA mitochondrion
GO:0006351 IEA transcription, DNA-templated
GO:0006355 TAS:IEA regulation of transcription, DNA-templated
GO:0006367 TAS transcription initiation from RNA polymerase II promoter
GO:0007165 TAS signal transduction
GO:0007267 TAS cell-cell signaling
GO:0007420 IEA brain development
GO:0008270 IEA zinc ion binding
GO:0008285 IEA negative regulation of cell proliferation
GO:0008628 IEA hormone-mediated apoptotic signaling pathway
GO:0010467 TAS gene expression
GO:0019899 IPI enzyme binding
GO:0030284 TAS estrogen receptor activity
GO:0030308 NAS negative regulation of cell growth
GO:0030520 TAS intracellular estrogen receptor signaling pathway
GO:0034056 IDA estrogen response element binding
GO:0042127 IEA regulation of cell proliferation
GO:0043401 IEA steroid hormone mediated signaling pathway
GO:0043565 IEA sequence-specific DNA binding
GO:0048019 NAS receptor antagonist activity
GO:0050680 IEA negative regulation of epithelial cell proliferation
GO:0051091 IDA positive regulation of sequence-specific DNA binding transcription factor activity
GO:0060065 IEA uterus development
GO:0060068 IEA vagina development
GO:0060740 IEA prostate gland epithelium morphogenesis
GO:0060743 IEA epithelial cell maturation involved in prostate gland development
GO:0060766 IEA negative regulation of androgen receptor signaling pathway
GO:1900116 NAS extracellular negative regulation of signal transduction

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000016454 esr2a estrogen receptor 2a protein_coding Danio_rerio
ENSDARG00000034181 esr2b estrogen receptor 2b protein_coding Danio_rerio
ENSMUSG00000021055 Esr2 estrogen receptor 2 (beta) protein_coding Mus_musculus

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