C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: protein phosphatase 1A, magnesium dependent, alpha isoform
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000021096 Ppm1a 10090 + 12:72761211-72794940 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000021514 Ppm1a-201 72761211-72794940 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000021514
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000021514 23.524±3.51 28.437±9.32 34.041±1.06 22.961±3.87 20.577±5.74 21.229±0.66 15.761±7.02 16.750±3.83 19.247±2.00 16.477±1.59 30.146±13.07 15.843±5.82 19.698±4.83 56.192±11.05

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00036H CIL_00036H_0003 CGP 12:72650356-72794940
CIL_0008MW CIL_0008MW_0002 VISTA 12:72750612-73352572
CIL_0000S6 CIL_0000S6_0002 CGP 12:72761211-72940774

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000287 IEA magnesium ion binding
GO:0004721 IDA phosphoprotein phosphatase activity
GO:0004871 IEA signal transducer activity
GO:0005515 IEA protein binding
GO:0005634 IEA nucleus
GO:0005829 IDA cytosol
GO:0005891 IEA voltage-gated calcium channel complex
GO:0006470 IDA protein dephosphorylation
GO:0006499 IDA N-terminal protein myristoylation
GO:0008022 IEA protein C-terminus binding
GO:0010991 IEA negative regulation of SMAD protein complex assembly
GO:0016020 IDA membrane
GO:0016055 IEA Wnt signaling pathway
GO:0016311 IEA dephosphorylation
GO:0030145 IEA manganese ion binding
GO:0030177 IEA positive regulation of Wnt signaling pathway
GO:0030512 IEA negative regulation of transforming growth factor beta receptor signaling pathway
GO:0033192 IEA calmodulin-dependent protein phosphatase activity
GO:0035970 IEA peptidyl-threonine dephosphorylation
GO:0042347 ISS negative regulation of NF-kappaB import into nucleus
GO:0043005 IEA neuron projection
GO:0043123 IEA positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043124 ISS negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045893 IEA positive regulation of transcription, DNA-templated
GO:0070412 ISS R-SMAD binding

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000032155 ppm1aa protein phosphatase, Mg2+/Mn2+ dependent, 1Aa protein_coding Danio_rerio
ENSDARG00000043250 ppm1ab protein phosphatase, Mg2+/Mn2+ dependent, 1Ab protein_coding Danio_rerio
ENSG00000100614 PPM1A protein phosphatase, Mg2+/Mn2+ dependent, 1A protein_coding Homo_sapiens

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