C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: protein phosphatase, Mg2+/Mn2+ dependent, 1A
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000100614 PPM1A 9606 + 14:60245752-60299087 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000325642 PPM1A-009 60245752-60292731 protein_coding
  ENST00000325658 PPM1A-002 60249441-60288555 protein_coding
  ENST00000395076 PPM1A-001 60249268-60299087 protein_coding
  ENST00000525399 PPM1A-006 60250431-60283266 protein_coding
  ENST00000528241 PPM1A-008 60249660-60283089 protein_coding
  ENST00000531143 PPM1A-005 60245757-60292482 nonsense_mediated_decay
  ENST00000531937 PPM1A-007 60256762-60283147 protein_coding
  ENST00000532036 PPM1A-004 60245785-60293355 nonsense_mediated_decay

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000325642ENST00000325658ENST00000395076ENST00000525399ENST00000531143ENST00000531937ENST00000532036
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000325642 8.040±0.00 5.227±0.00 N/A N/A 6.107±0.00 N/A 11.310±0.00 8.765±0.00 4.397±0.00 6.159±0.00 4.030±0.00 4.289±0.00 2.260±0.00 13.947±7.74
ENST00000325658 2.406±0.00 1.532±0.00 1.680±0.00 4.834±0.33 2.204±0.39 2.574±0.00 1.878±0.28 1.832±0.00 3.844±0.00 2.942±1.31 N/A 2.040±0.73 0.988±0.00 N/A
ENST00000395076 4.070±0.00 1.797±0.00 3.517±0.00 10.444±0.82 3.970±0.45 6.652±0.13 5.494±0.33 4.848±1.63 4.468±2.83 4.581±2.01 9.680±5.37 2.790±0.27 1.774±0.95 4.356±0.31
ENST00000525399 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 6.514±0.00 6.189±0.00 26.565±0.00
ENST00000531143 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 5.462±0.00
ENST00000531937 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 36.779±0.00
ENST00000532036 6.611±0.00 6.814±0.00 N/A N/A 6.631±0.00 12.077±0.00 10.293±0.00 11.670±0.00 6.527±0.00 8.832±0.00 N/A 4.895±0.00 3.603±0.09 18.561±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00036H CIL_00036H_0002 CGP 14:60144120-60299087
CIL_0000S6 CIL_0000S6_0001 CGP 14:60245752-60515543

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 TAS negative regulation of transcription from RNA polymerase II promoter
GO:0000287 IEA magnesium ion binding
GO:0003824 IEA catalytic activity
GO:0004721 IEA phosphoprotein phosphatase activity
GO:0004722 IEA:IDA protein serine/threonine phosphatase activity
GO:0004871 IMP signal transducer activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005654 TAS nucleoplasm
GO:0005829 ISS cytosol
GO:0005891 IEA voltage-gated calcium channel complex
GO:0006351 TAS transcription, DNA-templated
GO:0006367 TAS transcription initiation from RNA polymerase II promoter
GO:0006470 IMP protein dephosphorylation
GO:0006499 ISS N-terminal protein myristoylation
GO:0007050 TAS cell cycle arrest
GO:0007179 TAS transforming growth factor beta receptor signaling pathway
GO:0008022 IEA protein C-terminus binding
GO:0008152 IEA metabolic process
GO:0008286 TAS insulin receptor signaling pathway
GO:0010467 TAS gene expression
GO:0010991 IDA negative regulation of SMAD protein complex assembly
GO:0016020 ISS membrane
GO:0016055 IDA Wnt signaling pathway
GO:0016311 IDA dephosphorylation
GO:0030145 IEA manganese ion binding
GO:0030177 IDA positive regulation of Wnt signaling pathway
GO:0030512 IDA negative regulation of transforming growth factor beta receptor signaling pathway
GO:0033192 IDA calmodulin-dependent protein phosphatase activity
GO:0035970 IDA peptidyl-threonine dephosphorylation
GO:0042347 IMP negative regulation of NF-kappaB import into nucleus
GO:0043005 IEA neuron projection
GO:0043123 IMP positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043124 IMP negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045893 IDA positive regulation of transcription, DNA-templated
GO:0046872 IEA metal ion binding
GO:0070412 IPI R-SMAD binding

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000032155 ppm1aa protein phosphatase, Mg2+/Mn2+ dependent, 1Aa protein_coding Danio_rerio
ENSDARG00000043250 ppm1ab protein phosphatase, Mg2+/Mn2+ dependent, 1Ab protein_coding Danio_rerio
ENSMUSG00000021096 Ppm1a protein phosphatase 1A, magnesium dependent, alpha isoform protein_coding Mus_musculus

Loading