C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: twinfilin, actin-binding protein, homolog 1 (Drosophila)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000022451 Twf1 10090 - 15:94577951-94589889 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000023087 Twf1-001 94577951-94589879 protein_coding
  ENSMUST00000127347 Twf1-004 94581020-94581386 retained_intron
  ENSMUST00000152590 Twf1-002 94584443-94589889 protein_coding
  ENSMUST00000155654 Twf1-003 94579666-94585475 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000023087ENSMUST00000155654
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000023087 29.273±1.24 14.602±1.98 40.975±2.15 15.200±8.40 15.728±5.08 38.545±4.59 3.671±1.35 33.751±2.34 12.607±3.08 20.012±1.22 2.031±0.45 28.336±7.81 22.503±11.68 6.370±2.48
ENSMUST00000155654 N/A N/A N/A 8.274±0.00 N/A N/A N/A N/A N/A N/A N/A 20.927±0.00 27.339±9.19 5.179±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0006R6 CIL_0006R6_0002 CGP 15:94522688-94581815
CIL_0006R5 CIL_0006R5_0002 CGP 15:94543643-94589889
CIL_0006R8 CIL_0006R8_0002 CGP 15:94577951-95096097

Gene Ontology
GO IDEvidence TypeGO Description
GO:0003779 IEA actin binding
GO:0003785 IDA actin monomer binding
GO:0004713 IDA protein tyrosine kinase activity
GO:0005546 IDA phosphatidylinositol-4,5-bisphosphate binding
GO:0005622 IEA intracellular
GO:0005911 IDA cell-cell junction
GO:0015629 IDA actin cytoskeleton
GO:0018108 IDA peptidyl-tyrosine phosphorylation
GO:0030016 IDA myofibril
GO:0030175 IDA filopodium
GO:0030837 IDA negative regulation of actin filament polymerization
GO:0032587 IDA ruffle membrane
GO:0042989 IDA sequestering of actin monomers
GO:0048471 IDA perinuclear region of cytoplasm
GO:0051016 IDA barbed-end actin filament capping

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000011661 twf1b twinfilin, actin-binding protein, homolog 1b protein_coding Danio_rerio
ENSDARG00000035844 twf1a twinfilin, actin-binding protein, homolog 1a protein_coding Danio_rerio
ENSDARG00000090533 TWF1 (3 of 3) twinfilin actin-binding protein 1 protein_coding Danio_rerio
ENSG00000151239 TWF1 twinfilin actin-binding protein 1 protein_coding Homo_sapiens

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