C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: sine oculis-related homeobox 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000024134 Six2 10090 - 17:85684277-85688274 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000024947 Six2-201 85684282-85688254 protein_coding
  ENSMUST00000163568 Six2-001 85684277-85688274 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000024947ENSMUST00000163568
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000024947 0.201±0.09 0.239±0.12 0.040±0.00 0.386±0.04 0.356±0.34 0.787±0.30 0.260±0.05 0.153±0.07 0.089±0.06 0.307±0.18 N/A 0.618±0.19 0.219±0.09 1.117±0.30
ENSMUST00000163568 0.016±0.00 N/A 0.121±0.02 0.576±0.12 N/A 0.358±0.16 0.055±0.02 N/A 0.045±0.03 0.038±0.02 9.432±0.53 0.050±0.00 0.864±1.10 1.083±0.32

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007KD CIL_0007KD_0002 UCNEbase 17:85172000-86036297
CIL_00083B CIL_00083B_0002 VISTA 17:85187468-85789670
CIL_0009CD CIL_0009CD_0002 VISTA 17:85226742-85830634
CIL_0009CC CIL_0009CC_0002 VISTA 17:85262619-85863333
CIL_0007WX CIL_0007WX_0002 VISTA 17:85278835-85879978
CIL_0001NN CIL_0001NN_0002 CGP 17:85613608-85688274
CIL_0000RS CIL_0000RS_0002 CGP 17:85684277-86145175

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001656 IMP metanephros development
GO:0001822 ISS kidney development
GO:0002062 IMP chondrocyte differentiation
GO:0003337 IEP mesenchymal to epithelial transition involved in metanephros morphogenesis
GO:0003700 IDA sequence-specific DNA binding transcription factor activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0006606 IDA protein import into nucleus
GO:0007501 IDA mesodermal cell fate specification
GO:0008134 IPI transcription factor binding
GO:0008283 ISS cell proliferation
GO:0009948 IDA anterior/posterior axis specification
GO:0016477 ISS cell migration
GO:0030278 IMP regulation of ossification
GO:0032330 IMP regulation of chondrocyte differentiation
GO:0032403 IDA protein complex binding
GO:0042474 IGI middle ear morphogenesis
GO:0043565 IDA sequence-specific DNA binding
GO:0045596 IMP negative regulation of cell differentiation
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0048557 IMP embryonic digestive tract morphogenesis
GO:0048701 IMP embryonic cranial skeleton morphogenesis
GO:0048704 IGI embryonic skeletal system morphogenesis
GO:0072006 IMP nephron development
GO:0072028 IMP nephron morphogenesis
GO:0072038 IMP mesenchymal stem cell maintenance involved in nephron morphogenesis
GO:0072161 IMP mesenchymal cell differentiation involved in kidney development
GO:0090189 IMP regulation of branching involved in ureteric bud morphogenesis
GO:0097168 IMP mesenchymal stem cell proliferation
GO:1902732 IMP positive regulation of chondrocyte proliferation

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000058004 six2a sine oculis-related homeobox 2a protein_coding Danio_rerio
ENSG00000170577 SIX2 SIX homeobox 2 protein_coding Homo_sapiens

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