C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: aminolevulinic acid synthase 2, erythroid
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000025270 Alas2 10090 + X:150547375-150570638 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000066337 Alas2-001 150547375-150570638 protein_coding
  ENSMUST00000112715 Alas2-002 150547459-150570622 protein_coding
  ENSMUST00000134670 Alas2-003 150554037-150557663 retained_intron
  ENSMUST00000142474 Alas2-004 150566390-150570622 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungOvaryPlacentaTestisENSMUST00000066337ENSMUST00000112715
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Ovary Placenta Testis
ENSMUST00000066337 3.979±0.78 N/A 0.798±0.00 5.308±4.14 3.587±0.00 1.712±0.01 66.992±49.56 6.922±1.24 201.144±214.02 22.777±8.14 2.400±0.67 34.434±13.22 5.967±2.50
ENSMUST00000112715 N/A 2.470±0.19 N/A N/A N/A 2.238±1.37 73.926±4.29 5.298±1.05 89.774±94.57 21.422±11.66 2.796±0.66 22.778±14.00 4.492±1.22

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0000YC CIL_0000YC_0002 CGP X:150519519-150589868

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001666 ISS response to hypoxia
GO:0003870 ISS 5-aminolevulinate synthase activity
GO:0005515 IEA protein binding
GO:0005739 ISS mitochondrion
GO:0005743 ISS mitochondrial inner membrane
GO:0005759 IEA mitochondrial matrix
GO:0006782 IEA protoporphyrinogen IX biosynthetic process
GO:0006783 IMP heme biosynthetic process
GO:0006879 IMP cellular iron ion homeostasis
GO:0030170 IEA pyridoxal phosphate binding
GO:0030218 IMP erythrocyte differentiation
GO:0042541 IMP hemoglobin biosynthetic process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000038643 alas2 aminolevulinate, delta-, synthetase 2 protein_coding Danio_rerio
ENSG00000158578 ALAS2 aminolevulinate, delta-, synthase 2 protein_coding Homo_sapiens

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