C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: DNA-damage inducible transcript 3
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000025408 Ddit3 10090 + 10:127290774-127296288 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000026475 Ddit3-001 127290774-127296288 protein_coding
  ENSMUST00000134686 Ddit3-003 127290794-127294582 retained_intron
  ENSMUST00000139091 Ddit3-002 127290793-127296065 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000026475ENSMUST00000139091
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000026475 18.013±0.51 35.112±4.10 27.062±1.84 34.667±0.00 19.043±2.50 17.640±2.02 11.079±0.29 15.682±0.91 26.246±9.29 14.748±1.82 16.685±2.66 40.729±9.17 38.401±13.31 56.003±10.26
ENSMUST00000139091 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 71.242±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0003A8 CIL_0003A8_0002 CGP 10:127281956-127296288
CIL_0003A7 CIL_0003A7_0002 CGP 10:127290774-127311786

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001955 IMP blood vessel maturation
GO:0003677 IDA DNA binding
GO:0003700 IMP sequence-specific DNA binding transcription factor activity
GO:0005515 IPI protein binding
GO:0005634 IC nucleus
GO:0005770 IDA late endosome
GO:0006355 IMP regulation of transcription, DNA-templated
GO:0006915 IMP apoptotic process
GO:0006983 IMP ER overload response
GO:0006986 IEA response to unfolded protein
GO:0007050 IEA cell cycle arrest
GO:0008134 IEA transcription factor binding
GO:0016055 IEA Wnt signaling pathway
GO:0030968 IMP endoplasmic reticulum unfolded protein response
GO:0032757 IEA positive regulation of interleukin-8 production
GO:0034976 IDA response to endoplasmic reticulum stress
GO:0042594 IDA response to starvation
GO:0042789 IEA mRNA transcription from RNA polymerase II promoter
GO:0043161 IEA proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043433 IEA negative regulation of sequence-specific DNA binding transcription factor activity
GO:0043525 IMP positive regulation of neuron apoptotic process
GO:0043565 IEA sequence-specific DNA binding
GO:0044324 IDA regulation of transcription involved in anterior/posterior axis specification
GO:0045454 IEA cell redox homeostasis
GO:0045662 IMP negative regulation of myoblast differentiation
GO:0045892 IMP negative regulation of transcription, DNA-templated
GO:0045893 IDA positive regulation of transcription, DNA-templated
GO:0045944 IEA positive regulation of transcription from RNA polymerase II promoter
GO:0051209 IMP release of sequestered calcium ion into cytosol
GO:0070059 IMP intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0090090 IDA negative regulation of canonical Wnt signaling pathway
GO:2000016 IDA negative regulation of determination of dorsal identity

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000059836 ddit3 DNA-damage-inducible transcript 3 protein_coding Danio_rerio
ENSG00000175197 DDIT3 DNA-damage-inducible transcript 3 protein_coding Homo_sapiens

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