C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: protein tyrosine phosphatase, non-receptor type 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000027540 Ptpn1 10090 + 2:167932057-167979385 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000029053 Ptpn1-001 167932327-167979385 protein_coding
  ENSMUST00000124039 Ptpn1-003 167932395-167967733 processed_transcript
  ENSMUST00000126839 Ptpn1-002 167932372-167979385 processed_transcript
  ENSMUST00000142717 Ptpn1-005 167951048-167965067 processed_transcript
  ENSMUST00000144249 Ptpn1-004 167932395-167963687 processed_transcript
  ENSMUST00000147210 Ptpn1-006 167932057-167974737 processed_transcript
  ENSMUST00000151705 Ptpn1-007 167932372-167967785 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000029053ENSMUST00000126839ENSMUST00000147210ENSMUST00000151705
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000029053 16.230±4.47 30.719±0.47 16.318±1.17 14.698±9.54 35.090±18.05 15.922±6.89 5.444±1.33 9.228±4.30 8.928±1.74 32.640±4.55 5.443±0.79 29.051±14.17 6.118±3.18 11.586±5.80
ENSMUST00000126839 N/A N/A N/A 1.538±0.00 N/A N/A N/A 1.355±0.00 1.013±0.00 N/A N/A N/A 1.501±0.07 0.348±0.00
ENSMUST00000147210 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 12.432±0.00 5.172±1.49 N/A
ENSMUST00000151705 N/A N/A N/A 18.430±0.00 N/A N/A N/A N/A N/A N/A N/A 40.579±0.00 21.456±0.91 27.383±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007ZW CIL_0007ZW_0002 VISTA 2:167542374-168145654
CIL_0007H3 CIL_0007H3_0002 CGP 2:167688915-167979385
CIL_0007VZ CIL_0007VZ_0002 VISTA 2:167749064-168350864
CIL_0007GS CIL_0007GS_0002 CGP 2:167932057-168010618

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004725 ISS protein tyrosine phosphatase activity
GO:0005158 IEA insulin receptor binding
GO:0005515 IEA protein binding
GO:0005769 ISS early endosome
GO:0005783 IEA endoplasmic reticulum
GO:0005829 TAS cytosol
GO:0005886 ISS plasma membrane
GO:0006470 IMP protein dephosphorylation
GO:0008270 IEA zinc ion binding
GO:0008286 IMP insulin receptor signaling pathway
GO:0009966 ISS regulation of signal transduction
GO:0019899 IEA enzyme binding
GO:0019901 IEA protein kinase binding
GO:0030100 ISS regulation of endocytosis
GO:0030948 IGI negative regulation of vascular endothelial growth factor receptor signaling pathway
GO:0030968 ISS endoplasmic reticulum unfolded protein response
GO:0030971 IEA receptor tyrosine kinase binding
GO:0031410 IEA cytoplasmic vesicle
GO:0031532 ISS actin cytoskeleton reorganization
GO:0035335 ISS peptidyl-tyrosine dephosphorylation
GO:0035791 IMP platelet-derived growth factor receptor-beta signaling pathway
GO:0044822 IEA poly(A) RNA binding
GO:0046626 IEA regulation of insulin receptor signaling pathway
GO:0046875 IEA ephrin receptor binding
GO:0070373 IGI negative regulation of ERK1 and ERK2 cascade
GO:0097443 IDA sorting endosome
GO:1902202 IEA regulation of hepatocyte growth factor receptor signaling pathway
GO:1990264 IGI peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000007923 ptpn1 protein tyrosine phosphatase, non-receptor type 1 protein_coding Danio_rerio
ENSG00000196396 PTPN1 protein tyrosine phosphatase, non-receptor type 1 protein_coding Homo_sapiens

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