C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: transformation related protein 73
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000029026 Trp73 10090 - 4:154056253-154140208 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000097762 Trp73-007 154058512-154097173 protein_coding
  ENSMUST00000097763 Trp73-005 154058989-154097167 nonsense_mediated_decay
  ENSMUST00000105643 Trp73-004 154058989-154097167 protein_coding
  ENSMUST00000105644 Trp73-001 154056253-154140208 protein_coding
  ENSMUST00000133533 Trp73-002 154056253-154097173 protein_coding
  ENSMUST00000139634 Trp73-003 154067698-154116605 protein_coding
  ENSMUST00000155642 Trp73-006 154064445-154085322 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonKidneyLiverLungMuscleOvaryPlacentaENSMUST00000097762ENSMUST00000097763ENSMUST00000105643ENSMUST00000105644ENSMUST00000133533ENSMUST00000139634ENSMUST00000155642
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Kidney Liver Lung Muscle Ovary Placenta
ENSMUST00000097762 N/A 0.010±0.00 N/A N/A 0.150±0.11 0.112±0.00 0.027±0.01 0.004±0.00 0.578±0.00 0.020±0.01 0.808±0.36 0.002±0.00
ENSMUST00000097763 N/A N/A N/A 0.170±0.00 N/A N/A N/A N/A N/A 0.023±0.00 0.985±0.00 0.033±0.04
ENSMUST00000105643 N/A N/A N/A N/A N/A 0.085±0.03 N/A 0.005±0.00 N/A 0.022±0.01 N/A 0.019±0.00
ENSMUST00000105644 0.026±0.00 0.032±0.01 0.021±0.00 0.449±0.10 N/A 0.065±0.06 0.014±0.00 0.018±0.00 N/A N/A 0.442±0.00 N/A
ENSMUST00000133533 0.005±0.00 0.008±0.00 0.008±0.00 0.558±0.08 0.108±0.04 0.087±0.00 0.008±0.00 0.011±0.00 N/A 0.012±0.00 0.328±0.17 0.011±0.01
ENSMUST00000139634 0.034±0.00 N/A N/A N/A N/A 0.143±0.00 0.076±0.00 N/A N/A N/A 1.882±0.19 N/A
ENSMUST00000155642 0.031±0.00 0.035±0.00 N/A N/A N/A 0.072±0.00 N/A N/A N/A 0.116±0.00 1.665±0.00 0.016±0.00

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IBA negative regulation of transcription from RNA polymerase II promoter
GO:0000187 IEA activation of MAPK activity
GO:0000785 IBA chromatin
GO:0001822 IEA kidney development
GO:0001836 IDA release of cytochrome c from mitochondria
GO:0002039 IPI p53 binding
GO:0003677 IDA DNA binding
GO:0003682 IBA chromatin binding
GO:0003684 IBA damaged DNA binding
GO:0003690 IBA double-stranded DNA binding
GO:0003700 ISO sequence-specific DNA binding transcription factor activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005667 IBA transcription factor complex
GO:0005829 IBA cytosol
GO:0006351 IEA transcription, DNA-templated
GO:0006954 IMP inflammatory response
GO:0006974 IMP cellular response to DNA damage stimulus
GO:0006978 IBA DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
GO:0007050 IDA cell cycle arrest
GO:0007346 ISO regulation of mitotic cell cycle
GO:0008134 IEA transcription factor binding
GO:0009791 IMP post-embryonic development
GO:0010165 IBA response to X-ray
GO:0010243 IEA response to organonitrogen compound
GO:0010332 IBA response to gamma radiation
GO:0010468 ISO regulation of gene expression
GO:0019901 IEA protein kinase binding
GO:0021766 IMP hippocampus development
GO:0030900 IMP forebrain development
GO:0031571 IBA mitotic G1 DNA damage checkpoint
GO:0033326 IMP cerebrospinal fluid secretion
GO:0034644 IBA cellular response to UV
GO:0042771 IBA:ISS intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0042802 IEA identical protein binding
GO:0043065 IEA positive regulation of apoptotic process
GO:0043508 IDA negative regulation of JUN kinase activity
GO:0043523 IGI regulation of neuron apoptotic process
GO:0043524 IDA negative regulation of neuron apoptotic process
GO:0043565 IBA sequence-specific DNA binding
GO:0044212 IEA transcription regulatory region DNA binding
GO:0045665 IEA negative regulation of neuron differentiation
GO:0045793 IMP positive regulation of cell size
GO:0045893 ISO positive regulation of transcription, DNA-templated
GO:0045944 IBA:ISS positive regulation of transcription from RNA polymerase II promoter
GO:0046872 IEA metal ion binding
GO:0048546 IMP digestive tract morphogenesis
GO:0048666 IMP neuron development
GO:0048714 IEA positive regulation of oligodendrocyte differentiation
GO:0051262 IEA protein tetramerization
GO:0060044 ISO negative regulation of cardiac muscle cell proliferation
GO:1902167 IGI positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:2001235 IGI positive regulation of apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000017953 tp73 tumor protein p73 protein_coding Danio_rerio
ENSG00000078900 TP73 tumor protein p73 protein_coding Homo_sapiens

Loading